脱氧核苷酸钠穴位注射治疗肺癌化疗后白细胞减少症临床观察  

Sodium deoxyribonucleotide injection at Zusanli point for chemotherapy-induced leukopenia in patients with lung cancer

作　　者：杨丽型[1] 王东[1] 李学海[1] 马晨辰[1] 张建新[1] 

机构地区：[1]解放军第201医院综合科,辽阳111000

出　　处：《国际中医中药杂志》2015年第7期602-604,共3页International Journal of Traditional Chinese Medicine

摘　　要：目的：观察穴位注射脱氧核苷酸钠治疗肺癌化疗后白细胞减少症的疗效。方法本研究为随机对照研究。将符合纳入标准的116例非小细胞肺癌化疗后白细胞减少症患者按随机数字表法分为治疗组60例和对照组56例，治疗组予脱氧核苷酸钠双侧足三里穴位注射，对照组予同样剂量脱氧核苷酸钠静滴，5～7 d为1个疗程。采用血细胞分析仪检测2组治疗后3、5、7、10 d外周血中白细胞计数。结果治疗组、对照组总有效率分别为91.7%（55/60）、76.8%（43/56），2组比较差异有统计学意义（χ^2＝4.890， P＝0.032）。治疗组治疗后第3、5、7、10天，白细胞计数升高，有效例数分别为31例（51.7%）、46例（76.7%）、51例（85.0%）、47例（78.3%），均高于对照组的18例（32.1%）、30例（53.6%）、38例（67.9%）、30例（53.6%），2组比较差异均有统计学意义（χ^2值分别为4.530、6.840、4.770、7.960，P值分别为0.036、0.018、0.026、0.011）。结论穴位注射脱氧核苷酸钠可快速升高化疗后白细胞减少症患者的白细胞。Objective To evaluate thetherapeutic effect of sodium deoxyribonucleotide injection at Zusanli point for chemotherapy-induced leukopenia in patients with lung cancer.MethodsA total of 116 chemotherapy-induced leukopenia patients with lung cancer were randomly divided into a therapy group and a control group, 60 in the treatment group and 56 in the control group. The patients in the treatment group were treated with sodium deoxyribonucleotide injection atZusnlipoint, and those in the control group were treated with vein injection of sodium deoxyribonucleotide.Results The total effective rate in the treatment group was significant higher than that in the control group （91.7%vs.76.8%;χ^2=4.890,P=0.032）. The effective rates on days 3,5,7 and 10 in the treatment group were also significant higher than those in the control group （on day 3： 51.7%vs. 32.1%,χ^2=4.530,P=0.036; on day 5： 76.7%vs. 53.6%,χ^2=6.840,P=0.018; on day 7： 85.0%vs. 67.9%,χ^2=4.770,P=0.026; on day 10： 78.3%vs. 53.6%,χ^2=7.960,P=0.011）.Conclusion Sodium deoxyribonucleotide injection atZusanlipoint has definite efficacy for chemotherapy-induced leukopenia in patients with lung cancer.

关 键 词：白细胞减少症 抗肿瘤药 肺肿瘤 穴 足三里 脱氧核糖核苷酸类 穴位注射 

分 类 号：R734.2[医药卫生—肿瘤]