影响门静脉高压性胃病的多因素回归分析  

Influencing Factors and Significance of Portal Hypertensive Gastropathy in Liver Cirrhosis

作　　者：赵智[1] 罗俊卿[1] 刘小利[1] 段泽星[1] 

机构地区：[1]武警湖南总队医院,湖南长沙410006

出　　处：《医学临床研究》2015年第6期1180-1182,共3页Journal of Clinical Research

摘　　要：【目的】探讨肝硬化门脉高压性胃病（portal hypertensive gastropathy ，PHG）的影响因素及其意义。【方法】将158例肝硬化患者分为无 PHG 组、轻度 PHG 组与重度 PHG 组，比较各组终末期肝病模型（MELD）评分、血氨、血清白蛋白、腹水、食管静脉曲张程度、脾脏大小、门静脉内径、胃蛋白酶原比值（PGI／PGII ，PGR）、幽门螺杆菌（Hp）感染差异，随后进行多因素 Logistic 回归分析。【结果】不同组别肝硬化患者的 MELD 评分、血清白蛋白、食管静脉曲张程度、门静脉内径、PGR 比较差异具有统计学意义；多因素 Logistic 回归分析表明 MELD 评分、食管静脉曲张程度、门静脉内径、PGR 与PHG有较高相关度。【结论】肝硬化患者的MELD评分、食管静脉曲张程度、门静脉内径是 PHG 的危险因素，而PGR是PHG的保护因素，对于指导治疗及判断预后有一定帮助。[Objective] To explore the influencing factors and significance of portal hypertensive gastropathy （PHG） in liver cirrhosis .[Methods] A total of 158 cases of liver cirrhosis were divided into non‐PHG ,mild PHG and severe PHG groups .And the scores of model for end‐stage liver disease （MELD） were assessed .The profiles of blood ammonia ,serum albumin ,ascites ,esophageal varices ,spleen size ,diameter of main portal vein ,pepsino‐gen ratio （PGR） and HP infection were compared among three groups .Multivariate Logistic regression analyses were performed .[Results] The differences were statistically significant for MELD score ,serum albumin ,esopha‐geal varices ,diameter of main portal vein and PGR among three groups .Multivariate logistic regression analysis indicated that MELD score ,esophageal varices ,diameter of main portal vein and PGR were highly correlated with PHG .[Conclusion] MELD score ,esophageal varices and diameter of main portal vein are the risk factors .How‐ever ,PGR is a protective factor of PHG in liver cirrhosis .Thus it may guide the treatment and prognostic predication of PHG .

关 键 词：高血压  门静脉/并发症 胃疾病 危险因素 回归分析 食管和胃静脉曲张 

分 类 号：R573[医药卫生—消化系统]