肝细胞癌患者外周血单个核细胞Foxp3 mRNA水平变化  

Foxp3 mRNA in peripheral blood mononuclear cells in patients with hepatocellular carcinoma

作　　者：杨智[1] 陈洪涛[1] 吴诗品[1] 

机构地区：[1]暨南大学第二临床医学院深圳市人民医院感染内科,广东省深圳市518020

出　　处：《实用肝脏病杂志》2015年第4期395-398,共4页Journal of Practical Hepatology

基　　金：广东省科技厅青年自然科学基金资助项目(编号:D2011283)

摘　　要：目的检测初发现未治疗肝细胞癌(HCC)患者外周血单个核细胞(PBMCs)中Foxp3 m RNA水平变化及其与血清AFP水平的关系。方法在HCC患者60例和健康人20例,采用RT-PCR法检测PBMCs中Foxp3m RNA水平,常规检测血清AFP水平。结果 HCC患者和健康对照组外周血Foxp3 m RNA水平分别为(0.976±0.073)和(0.772±0.083),差异有统计学意义(P<0.01);经Pearson相关性分析显示,HCC患者外周血Foxp3 m RNA水平与AFP水平呈正相关(r=0.226,P=0.025)。结论 HCC患者PBMCs中Foxp3水平明显升高,对肿瘤的发生发展可能具有一定的预测作用。Objective To investigate Foxp3 mRNA levels in peripheral blood mononuclear cells （PBMCs） in patients with hepatocellular carcinoma （HCC） and explore its relationship with serum AFP levels. Methods 60 patients with HCC and 20 healthy persons were enrolled in this study. The Foxp3 mRNA in PBMCs was mea- sured by RT-PCR and serum AFP was detected at the same time. Results There existed statistically significant difference in Foxp3 levels between patients with HCC and controls [＇（0.976±0.073） vs.（0.772±0.083）,P〈0.01]; Pearson correlation analysis showed positive correlation between Foxp3 levels in PBMCs and serum AFP levels in HCC patients （r=0.226,P=0.025）. Conclusion The Foxp3 levels in PBMCs in patients with HCC increase,which might help predict HCC development.

关 键 词：肝细胞癌 FOXP3 外周血单个核细胞 甲胎蛋白 

分 类 号：R735.7[医药卫生—肿瘤]