加味黄芩汤预防晚期肠癌患者伊立替康化疗所致迟发性腹泻疗效观察  

Observation on the therapeutic effect of Jiawei Huangqin Tang on the prevention of delayed diarrhea caused by Irinotecan-based chemotherapy at the late stage of colorectal cancer

作　　者：于洋[1] 李晓松[2] 武冰[1] 姚芳芳[2] 张欢欢[2] 李素那[1] 钱丽旗[1] 

机构地区：[1]解放军总医院第一附属医院中医科,北京100048 [2]解放军总医院第一附属医院肿瘤科,北京100048

出　　处：《北京中医药》2015年第6期427-430,共4页Beijing Journal of Traditional Chinese Medicine

摘　　要：目的探讨加味黄芩汤对伊立替康(CPT-11)化疗所致迟发性腹泻的预防作用。方法 72例FOLFIRI方案化疗患者,按随机数字表法分为预防组34例和对照组38例。预防组于化疗前1日开始口服加味黄芩汤,连服1周。观察2组腹泻发生率及程度、化疗疗程改变的发生率、不良反应发生率。结果预防组腹泻发生率、化疗疗程改变发生率、恶心呕吐发生率均低于对照组,差异有统计学意义(P<0.05)。结论加味黄芩汤可预防CPT-11化疗所致迟发性腹泻,减少恶心呕吐的发生,提高化疗方案的依从性,改善晚期肠癌患者化疗期间的生活质量。Objective To explore the preventative actions of Jiawei Huangqin Tang on delayed diarrhea caused by Irinotecan （ CPT- 11 ） -based chemotherapy. Methods 72 FOLFIRI chemotherapy treated patients were randomly divided into a prevention group of 34 and a control group of 38. The control group received standard FOLFIRI chemotherapy only, while the prevention group began to orally take Jiawei Huangqin Tang one day before chemotherapy altogether for one week. Then, the occurrence rate and severity of diarrhea, the occurrence rate of chemotherapy course changes, and the occurrence rate of adverse reactions in both groups were observed. Results The occurrence rate of diarrhea, chemotherapy course changes, nausea and vomiting in the prevention group were all lower than that in the control group, the difference was statistically significant （ P 〈 O. 05 ）. Conclusion Jiawei Huangqin Tang can prevent delayed diarrhea caused by CPT-11 chemotherapy, reduce the occurrence of nausea and vomiting, increase the compliance for chemotherapy regimen, and improve the quality of life of patients with advanced colorectal cancer during chemotherapy.

关 键 词：加味黄芩汤 肿瘤 伊立替康 化学疗法 迟发性腹泻 预防 

分 类 号：R735.3[医药卫生—肿瘤]