巩膜细胞外基质在高度近视眼发病机制中的作用研究进展  被引量:6

Scleral cell extracellular matrix in the pathogenesis of high myopia: recent advances

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作  者:侯静梅[1] 亢泽峰[1] 

机构地区:[1]青海大学研究生院,西宁市810016

出  处:《中华眼科医学杂志(电子版)》2015年第1期44-46,共3页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

摘  要:目前已经有研究证实,视网膜能够独立识别眼球的屈光状态并做出相应的反应,是眼球生长控制系统的感觉运动器。视觉传导的信号分子从视网膜传递到巩膜,最后引起巩膜的重塑。由于巩膜决定眼球的形状和大小,因此巩膜的变化是近视眼研究的焦点。目前已经有大量研究报道,眼球伸长的过程伴随着巩膜的广泛重塑。局部视网膜信号转化为调控巩膜重塑的信号后,可诱导细胞外基质的异常表达,并引起巩膜胶原纤维的改变,最终引起巩膜重塑。本文笔者就巩膜细胞外基质在高度近视眼发病机制中的作用进行综述。Currently,there is experimental evidence showing that retina encompasses an entire sensorimotor apparatus that controls eyeball growth by independently identifying the refractive state of the eye and making appropriate responses accordingly. It is known that visual signals are transduced from the retina to the sclera,eventually reshaping the sclera. Given that the sclera determines the shape and size of the eyeball,the sclera has been the focus in myopia research. To date,numerous studies have demonstrated that: eyeball elongation is accompanied by the sclera remodeling and he local retinal signals,after transforming into remodeling-regulatory signals,may lead to aberrant expression of extracellular matrix components in the scleral cells and subsequent changes in the scleral collagen fibers. This paper aims to review the recent progress in the research on the role for scleral extracellular matrix in the pathogenesis of high myopia.

关 键 词:高度近视眼 发病机制 巩膜 细胞外基质 

分 类 号:R778.11[医药卫生—眼科]

 

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