响应曲面法优化厚朴酚-β-环糊精包合物的制备工艺  

Optimization of the preparation of magnolol-β-cyclodextrin inclusion compound by response surface methodology

作　　者：岳金金 张喜月[1] 刘金颖[1] 刘慧婷[1] 张玲[1] 

机构地区：[1]辽宁医学院畜牧兽医学院,辽宁锦州121001

出　　处：《中国饲料》2015年第13期17-20,共4页China Feed

基　　金：2013年辽宁省大学生创新创业训练计划项目(2013D41);2013年辽宁医学院校长基金-奥鸿博泽基金"大学生科技创新项目"

摘　　要：本试验运用响应曲面法优化厚朴酚-β-环糊精包合物的制备工艺。在单因素试验基础上,以β-环糊精与厚朴酚的比例、研磨时间、研磨温度为考察因素,采用响应曲面法优化包合工艺条件,模拟得到厚朴酚-β-环糊精包合物中厚朴酚含量的二次回归方程模型。最优包合条件:β-环糊精与厚朴酚的比例为4.9∶1、研磨时间31 min、研磨温度61℃,厚朴酚含量的实测结果(20.27%)与响应曲面拟合所得方程的预测值(20.59%)符合良好。采用响应曲面法优化厚朴酚包合物制备工艺得到的厚朴酚含量高,能很好地预测试验结果。Optimization of the preparation process of magnolol-β-cyclodextrin inclusion compound（Magnolol-β-CD）by response surface method.Based on the single-factor experiment,the quadratic regression model for the contents of magnolol in the magnolol-β-CD was established about the independent variables（the proportion of β-CD and magnolol,grind time and grind temperature）through Box-Behnken center composite design and response surface methodology.The optimum conditions were as follows：the proportion of β-CD and magnolol was 4.9∶1,grind time was 31 min and grind temperature was61℃.Under these conditions,the practical content of magnolol was 20.27%,which was consistent with the predicted content of magnolol（20.59%）.The preparation process model of inclusion compound established by response surface method could precisely predict the experiment results.In the best conditions deduced from the mode,the content of magnolol was high.

关 键 词：厚朴酚 Β-环糊精 包合物 响应曲面法 

分 类 号：S816.7[农业科学—饲料科学]