醒脑胶囊对拟血管性痴呆大鼠脑内GSH-PX和AchE活性影响的实验研究  

Experimental Study on the Effect of Xingnao Capsules on Ach E and GSH-PX in Brains of VD Rats

作　　者：高广生 高广慧 刘淑华 李智敏 聂亚东 张囡 孙秀琪 

机构地区：[1]哈尔滨市第四医院老年病科,黑龙江哈尔滨150001

出　　处：《中医药学报》2015年第3期39-41,共3页Acta Chinese Medicine and Pharmacology

基　　金：哈尔滨市科技创新人才专项基金(No.RC2013XK004003)

摘　　要：目的:通过拟血管性痴呆大鼠模型的给药治疗,探究新药醒脑胶囊对VD大鼠脑内谷胱甘肽过氧化物酶(GSH-PX)和乙酰胆碱酯酶(Ach E)活性以及学习记忆行为的影响和治疗机制。方法:将81只健康纯系Wistar老年大鼠随机分组:假手术组、模型组、中药组和西药对照组,然后利用2-血管阻断法(2-VO)制作VD大鼠模型。其中,中药组VD大鼠灌服醒脑胶囊蒸馏水混悬液。对VD大鼠治疗前后脑组织内GSH-PX和Ach E活性的改变以及穿梭箱行动能力测试结果进行比照分析。结果:统计分析表明,醒脑胶囊可有效增强VD大鼠脑组织中GSH-PX的活性,有效降低脑组织中Ach E活性,同时明显减少穿梭箱实验过程中VD大鼠的电击次数和电击时间。结论:治疗后的VD大鼠记忆学习能力明显改善,GSH-PX活性得到提高,而Ach E活性降低,表明醒脑胶囊能改善VD的痴呆程度,促进VD大鼠的智能恢复。Objective：To study the effect of Xingnao capsules on the activity of GSH-PX and AchE for learning dysmne-sia of VD rats.Methods：Select 81 healthy Wistar rats and they were divided into 4 groups.They were negative injury group, model group, Chinese medicine group and relative group.In the experiment, we adopted 2-VD to duplicate VD models and had rats taken aqueous solution of Xingnao capsules.By the end of the study, we examined the memory abil-ity of rats according to the shuttle test.Results：Xingnao capsules could promote the activities of GSH-PX and diminish the activities of AchE.Conclusion：Xingnao capsules could improve the learning and memory ability of models and pro-mote the activities of GSH-PX and decrease the activities of AchE.And it can promote the restoring function of injured neuron.

关 键 词：血管性痴呆 醒脑胶囊 谷胱甘肽过氧化物酶 乙酰胆碱酯酶 

分 类 号：R749.16[医药卫生—神经病学与精神病学]