儿童维生素D营养状况与骨密度关系的研究  

A study on the association between vitamin D status and ultrasonic bone mineral density among children

作　　者：孙慧[1] 郭俊霞[1] 留佩宁[1] 陈琪[1] 邵晓婷[1] 吴丽慧[1,2] 

机构地区：[1]温州医科大学附属第二医院育英儿童医院,浙江温州325003 [2]浙江医学高等专科学校

出　　处：《浙江预防医学》2015年第7期682-685,共4页Zhejiang Journal of Preventive Medicine

摘　　要：目的分析温州地区儿童维生素D营养状况与骨密度的关系。方法采集546名健康体检儿童晨间空腹静脉血,测定血清25（OH）D水平和骨密度（百分位数）。结果血清25（OH）D平均浓度为（25.42±0.590）ng/m L,维生素D充足率为25.09%,严重缺乏率、缺乏率和不足率分别为1.47%、32.60%和40.84%。血清25（OH）D浓度的年龄分布差异有统计学意义（P〈0.01）,年龄较大组低于年龄较小组;7岁~组和11~14岁组儿童血清25（OH）D浓度男童均高于女童（P〈0.05）。维生素D充足组的骨密度分别高于不足组和缺乏组（P〈0.05）。血清25（OH）D浓度与骨密度呈正相关（r=0.197,P〈0.01）,校正年龄与BMI后仍呈相关性（r=0.115,P〈0.01）。结论温州地区儿童维生素D营养状况不佳,血清25（OH）D浓度与骨密度呈正相关,应重视维生素D的补充。Objective To evaluate vitamin D nutritional status and its relationship with ultrasonic bone mineral density among children in Wenzhou City. Methods Overnight fasting venous blood samples of 546 children were collected to measure the concentration of serum 25- hydroxyvitamin D（ 25（ OH） D）,and bone mineral density was measured. Results The average concentration of serum 25（ OH） D was 25. 42 ± 0. 590 ng / m L,25. 09% of participants were found with sufficient vitamin D,the rate of severe deficiency,deficiency and insufficiency were 1. 47%,32. 60% and 40. 84%respectively. The concentration of 25（ OH） D in different age groups was statistically significantly different（ P 0. 01）.Vitamin D nutritional status of the older groups was poor than that of the younger ones. In the group of children aged 7 to 11 and 11 to 14,the levels of 25（ OH） D of boy was significantly higher than that of girl. Compared to those with sufficient vitamin D,children with vitamin D deficiency or insufficiency had lower bone mineral density（ BMD）（ P 0. 05）. The level of 25（ OH） D was correlated with BMD（ r = 0. 197,P 0. 01）. After adjusted age and BMI,there was still a positive correlation between 25（ OH） D level and BMD（ r = 0. 115,P 0. 01）. Conclusions The vitamin D level of children in Wenzhou area is low. The level of serum 25（ OH） D may be related to BMD. More attention should be paid to the supplementation of vitamin D.

关 键 词：维生素D 营养状况 25-羟维生素D 骨密度 儿童 

分 类 号：R151[医药卫生—营养与食品卫生学]