吉非替尼对肺鳞癌患者免疫功能的影响及其近期临床疗效  

Effect of gefitinib on immune function and clinical efficacy in patients with lung squamous cell cancer

作　　者：张丹[1] 杨光[1] 张曙光[1] 

机构地区：[1]中国医科大学附属第一医院胸外科,辽宁沈阳110031

出　　处：《安徽医药》2015年第7期1367-1370,共4页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学青年基金项目(No 81201890);辽宁省自然科学基金项目(No 2013021002)

摘　　要：目的研究吉非替尼对肺鳞癌患者免疫功能的影响及其近期临床疗效。方法选取诊断为肺鳞癌的患者84例,随机分为观察组和对照组,每组均为42例,两组患者均给予常规治疗,观察组在常规治疗的基础上给予口服吉非替尼,观察两组患者治疗后体液免疫和细胞免疫功能情况及其近期临床疗效。结果治疗后两组患者血清CD3、CD4、Ig G、Ig M、Ig A浓度与CD4/CD8较治疗前有所降低(P<0.05),CD8较治疗前有所升高(P<0.05);观察组患者血清CD3、CD4、CD4/CD8、Ig G、Ig M、Ig A浓度明显高于对照组(P<0.05),观察组CD8较对照组低(P<0.05);观察组临床疗效优于对照组,治疗后两组均出现恶心、恶心伴呕吐、骨髓抑制,差异无统计学意义(P>0.05)。结论在常规治疗的基础上给予口服吉非替尼能改善患者的免疫功能,提高临床疗效,且无严重不良反应。Objective To study the effect of gefitinib on immune function and clinical efficacy in patients with lung squamous cell canc-er.Methods Eighty-four patients who suffered from lung squamous cell cancer were randomized into observation group and control group.They were treated with conventional treatment,and the observation group took oral Gefitinib on this basis.The concentration of tumour markers in serum and efficacy were observed and compared between the two groups after treatment.Results After treatment, the concentration of CD3,CD4,IgG,IgM,IgA and CD4 /CD 8were lower than pretreatment levels（P 〈0.05）,the concentration of CD 8 was higher than pretreatment levels（P 〈0.05）,and the concentration of CD3,CD4,IgG,IgM,IgA and CD4 /CD8 in the observation group were significantly higher than those in the control group（P 〈0.05）,the concentration of CD8 in the observation group was signif-icantly lower than that in the control group（P 〈0.05）.After treatment,the clinical efficiency in the observation group was significantly higher than control group.After treatment,nausea,nausea plus vomit,and myelosuppression occurred in both groups,which had no sta-tistical difference（P 〉0.05）.Conclusions Gefitinib can improve the immune function and raise the clinical efficiency of patients with lung squamous cell cancer.

关 键 词：食管癌 吉非替尼 免疫功能 临床疗效 

分 类 号：R734.2[医药卫生—肿瘤]