酸蚀喷砂微螺钉种植体骨界面的组织学观察  

Bone surface of SLA microscrew implant: a histological observation

作　　者：武秀萍[1] 熊雯[1] 李冰[1] 李世峰 冯云霞[1] 

机构地区：[1]山西医科大学口腔医院正畸科,太原030001 [2]School of Dentistry Kyungpook National University

出　　处：《中国药物与临床》2015年第6期744-745,I0001,共3页Chinese Remedies & Clinics

基　　金：国家自然科学基金(81400553);山西省科技厅工业攻关项目(20100321104)

摘　　要：目的研究酸蚀喷砂(SLA)处理的微螺钉种植体骨界面的组织形态学变化情况。方法选择6只成年Beagle犬,将36个微螺钉种植体,随机分为2组,SLA组(n=18),对照组(n=18)。在下颌骨左右侧各选择3个植入部位,在实验开始、实验4周、实验6周不同时间点,于下颌骨左右侧植入SLA种植体及未处理种植体各1枚,实验8周时处死6只实验动物,获得愈合2周、4周、8周的骨组织标本,苏木精-伊红(HE)染色观察种植体骨界面组织学变化。结果 SLA组2周时,镜下可见破骨细胞和骨陷窝,成骨细胞表现活跃并伴许多新生骨的出现;对照组可见成骨细胞比较少,纤维组织比较多并紊乱排列。4周时,对照组显示新生骨增多,但成骨细胞不规则排列;SLA组可见成骨细胞进行有序的排列,骨小梁增多,骨质成熟。SLA组与对照组8周时,均可见骨小梁交织连接,呈现致密骨基质。结论微种植体表面进行SLA处理后,植入初期可促进微种植体骨界面成骨细胞的形成,利于提高微种植体骨整合率。Objective To investigate the histomorphological change in bone surface of sandblasted, large-grit, and acid-etched （SLA） microscrew implant. Methods Six adult Beagle dogs were included in the study. A total of 36 microscrew implants were randomly divided into two groups, the SLA group and the control group （n=18 each）. Three implant positions were selected at each of the left and right sides of the mandible, respectively. At the different time points （baseline, 4 weeks and 6 weeks of the experiment）, one SLA implant and untreated implant were implanted each at the left and right sides of the mandible, respectively. Six experimental animals were executed at 8 weeks of the experiment. The bone tissue samples at 2, 4 and 8 weeks of the experiment were obtained. The histological changes of the bone surfaces of the implants were observed by HE staining. Results At 2 weeks, the SLA group exhibited osteoclasts, bone lacuna, and active osteoblasting with massive new bone formation as found under microscope, compared with few osteoblasts and lots of deranged fibrous tissues in the control group. At 4 weeks, the control group showed increased new bones and disarrayed osteoblasts, compared with regularly arranged osteoblasts, increased bone trabecula and mature bones found in the SLA group. Connected bone trabeculae with high density bone matrix were found in both the SLA group and the control group at 8 weeks. Conclusion The formation of osteoblasts at the bone surface of SLA microscrew implant can be promoted early during implantation period, which favors the increase of osseointegration rate of microscrew implant.

关 键 词：牙种植体 牙种植 骨内 酸蚀 牙 

分 类 号：R783.6[医药卫生—口腔医学]