大连獐子岛居民ALDH_2rs71和MTHFRrs1801133基因及等位基因频率分布及与血压的关系  

The Relationship between SNPs of ALDH_2rs71 and MTHFRrs1801133 and Blood Pressure in Residents of Dalian Zhangzi Island

作　　者：刘桐含昱 宗成国[1] 刘官洪 刘新涛 刘欣[3] 刘文志[1] 王兴宇[3] 于勤[1] 

机构地区：[1]大连大学附属中山医院,辽宁大连116001 [2]大连长海县獐子岛中心卫生院,辽宁大连116503 [3]北京高血压联盟研究所人类基因学实验室,北京100043

出　　处：《大连大学学报》2015年第3期90-95,共6页Journal of Dalian University

基　　金：大连市科技计划项目(2014E14SF149)

摘　　要：对资料完整的170例獐子岛原住居民在心血管病相关问卷调查基础上,应用Taq Man RT-PCR法检测乙醛脱氢酶2(ALDH2)和甲基四氢叶酸还原酶(MTHFR)基因型,探讨等位基因分布频率及与血压的关系。发现ALDH2 AA+AG基因频率男性为35.3%,女性为21.9%,ALDH2 GG基因频率男性为64.8%,女性为78.1%。MTHFR AA、AG、GG基因频率男性为19.6%、54.9%、11.8%,女性为23.5%、53.8%、18.5%。大连獐子岛居民ALDH2、MTHFR基因及等位基因分布与不同收缩压和舒张压之间均无显著性,ALDH2与饮酒状况间差异无显著性;血压与ALDH2、MTHFR基因及等位基因型分布无明显的相关关系,基因型频率分布较广。To analyze the genotype frequency of aldehyde dehydrogenase-2（ALDH2）, methylenetetrahydrofolate reductase（MTHFR）and evaluate the relationship between ALDH2 polymorphism and drinking behavior, blood pressure in Zhangzi Island Population. Epidemiological data were collected from 170 participants in Zhangzi Island of Liaoning province in China. ALDH2 and MTHFR genotypes were detected by Taq Man real-time polymerase chain reaction（RT-PCR）. The frequency of ALDH2, as for AA＋AG, GG, they were 35.3% for men, 21.9% for women. The frequency of MTHFR, as for AA, AG, GG, they were 19.6%, 54.9%, 11.8% for men, 23.5%, 53.8%, 18.5% for women. No difference was found between ALDH2 AA＋AG and ALDH2 GG in alcohol history, no associations between blood pressure and ALDH2, MTHFR allelic frequency distribution. The distribution of ALDH2, MTHFR genotype is more widely in Zhangzi Island population.

关 键 词：乙醛脱氢酶2 甲基四氢叶酸还原酶 獐子岛 血压 等位基因频率 

分 类 号：R4[医药卫生—临床医学]