乙型肝炎病毒前S基因突变研究进展  

The mutation of hepatitis B virus pre-S gene

作　　者：李海波[1] 季兆东 郭陈[1] 

机构地区：[1]江苏省南通市疾病预防控制中心,226007 [2]江苏省南通体臣卫校,226010

出　　处：《中华临床医师杂志（电子版）》2015年第11期164-166,共3页Chinese Journal of Clinicians(Electronic Edition)

基　　金：江苏省预防医学科研课题(Y201010)

摘　　要：乙型肝炎病毒感染已成为世界范围内的严重公共卫生事件,可以引起急性、慢性病毒性肝炎,且与肝硬化及细胞性肝癌的发生高度相关。HBV基因的变异与病毒感染所致临床症状密切相关。本文对HBV前S基因的突变,以及该突变与细胞性肝癌的发生、乙型肝炎疫苗免疫失败、抗乙型肝炎药物治疗等的研究进展做一综述。Hepatitis B virus （HBV） infection has become a serious public health event in the world, which can lead to acute and chronic viral hepatitis, and is correlated with cirrhosis and hepatocellular carcinoma. I-IBV gene mutation is closely related to the symptoms. This review focused on the HBV pre-S gene mutation, and its relationship with occurrence ofhepatocarcinoma, immunity failure of HBV vaccine, and anti-I-IBV therapy.

关 键 词：肝炎病毒 乙型 前S基因 突变 

分 类 号：R373.21[医药卫生—病原生物学]