TSLC-1在甲状腺乳头状癌组织中的表达及临床意义  

Expression of TSLC-1 in human papillary thyroid carcinoma and its clinical significance

作　　者：胡华[1] 阳帅[2] 王晓瑜[1] 

机构地区：[1]南华大学附属第二医院病理科,湖南省衡阳市421001 [2]南华大学附属第一医院病理科,湖南省衡阳市421001

出　　处：《实用医学杂志》2015年第12期1922-1925,共4页The Journal of Practical Medicine

基　　金：国家自然科学青年基金资助(编号:81401960);湖南省教育厅课题资助(编号:14C0982)

摘　　要：目的:探讨TSLC-1蛋白表达与甲状腺乳头状癌发生发展的关系。方法:应用免疫组织化学方法检测TSLC-1蛋白在20例甲状腺良性病变和40例甲状腺乳头状癌组织中的表达。结果:TSLC-1在甲状腺乳头状癌中的阳性表达率为22.50%(9/40),低于甲状腺良性病变(90.00%)(P<0.05)。甲状腺乳头状癌中TSLC-1表达与淋巴结转移和TNM分期密切相关(P<0.05)。结论:TSLC-1表达与甲状腺乳头状癌的发生发展、淋巴结转移和临床分期密切相关。Objective To explore the relationship between TSLC-1 protein expression and the progression and carcinogenesis of human papillary thyroid carcinogenesis. Methods Expressions of TSLC-1 protein in 20 pieces of benign thyroid lesions and 40 pieces of papillary thyroid carcinoma tissues were examined by immunohistochemistry. Results The expression of TSLC-1 in papillary thyroid carcinoma （9/40） was lower than that in benign thyroid lesions （22.50% versus 90.00%, P 〈 0.05）. Expression of TSLC-1 was significantly associated with lymph node metastasis and TNM in papillary thyroid carcinoma （P 〈 0.05）. Conclusions Expression of TSLC-1 is closely related with carcinogenesis , lymph node metastasis , and clinical stage in papillary thyroid carcinoma.

关 键 词：TSLC1 甲状腺乳头状癌 免疫组织化学 

分 类 号：R736.1[医药卫生—肿瘤]