氟伏沙明联合羟考酮缓释片治疗中重度癌痛  

Fluvoxoxamine combined with oxycodone hydrochloride controlled-release tablets in treatment of moderate and severe cancer pain

作　　者：刘君[1] 肖扬[1] 马益敏[2] 常娟[1] 魏巍[1] 黄小红[1] 吴宜嘉[1] 郭建雄[1] 余波[1] 

机构地区：[1]江苏省泰兴市人民医院肿瘤科,225400 [2]江苏省泰兴市人民医院介入科,225400

出　　处：《实用医学杂志》2015年第12期2014-2017,共4页The Journal of Practical Medicine

基　　金：2014年泰州市科技支撑社会发展计划指导性项目(编号:54)

摘　　要：目的:观察氟伏沙明联合羟考酮缓释片治疗癌痛的疗效及安全性。方法:中、重度癌痛患者各120例,随机分为对照组和试验组,对照组给予羟考酮缓释片,试验组加用氟伏沙明片,至疼痛缓解,比较各组疼痛缓解程度、羟考酮缓释片用量、生活质量和副作用。结果:试验组较对照组疼痛缓解更明显,差异有统计学意义(P<0.05),羟考酮缓释片日均消耗量试验组低于对照组,中度癌痛无显著差异,重度癌痛有显著差异(P=0.035)。癌痛对生活质量的影响治疗后明显下降,试验组在一般状态、日常活动、情绪和睡眠方面改善优于对照组(P<0.05)。两组副反应近似,其中便秘发生率试验组低于对照组,有显著差异(P=0.026)。结论:氟伏沙明联合羟考酮缓释片能有效控制癌痛,减少羟考酮缓释片的用量及部分副作用,并改善生活质量。Objective To observe clinical efficacy and safety on the treatment of moderate-severe cancer pain by Fluvoxamine combined with Oxycodone. Methods 120 cancer patients with moderate pain and 120 cases with severe pain were selected, randomly divided into experimental group and control group. The control group were given oxycodone alone , and experimental group given fluvoxamine combined with oxycodone , till the pain relieved, then the degree of pain relief, oxycodone dosage, life quality and side effects were evaluated. Results The degree of pain relief in experimental group were much better than control group （P 〈 0.05）. Oxycodone consumption were lower in experimental group than control group , and the difference was no significant difference in controlling moderate pain （P = 0.065）, while statistically significant in controlling severe pain （P = 0.035）. The general status, daily activity, mood, and sleep affected by cancer pain were released after treatment, especially in experimental group （P 〈 0.05）. The most common side effects were approximative, and the incidence of constipation, nausea/vomiting, lethargy were lower in experimental group than control group （P =0.026）. Conclusion Fluvoxamine combined with Oxycodone can effectively control moderate-severe cancer pain, and reduce the oxycodone dosage and some side effects, and therefore, improve the quality of life.

关 键 词：癌痛 氟伏沙明 羟考酮缓释片 疗效 副反应 

分 类 号：R730.5[医药卫生—肿瘤]