雷贝拉唑联合阿莫西林、甲硝唑治疗十二指肠溃疡及根除幽门螺杆菌的疗效  

Efficacy of rabeprazole joint amoxicillin,metronidazole treatment of duodenal ulcer and Helicobacter pylori eradication

作　　者：陈志锋 

机构地区：[1]广东省海丰县梅陇人民医院,广东海丰516477

出　　处：《吉林医学》2015年第14期2987-2988,共2页Jilin Medical Journal

摘　　要：目的:研究雷贝拉唑联合阿莫西林、甲硝唑治疗十二指肠溃疡及根除幽门螺杆菌(Hp)的疗效。方法:将80例十二指肠溃疡病例均分为两组,每组40例。对照组给予奥美拉唑+阿莫西林+甲硝唑治疗,观察组给予雷贝拉唑+阿莫西林+甲硝唑治疗,观察两组疗效及Hp根除率。结果:观察组患者治疗1 d、7 d缓解率分别为75%、95%,明显高于对照组的52.5%、77.5%(P<0.05)。两组患者治疗有效率、Hp根除率及不良反应发生率差异无统计学意义(P>0.05)。结论:雷贝拉唑+阿莫西林+甲硝唑三连用药方案用于十二指肠溃疡治疗效果显著,起效时间短,安全性高,值得推广应用。Objective To study the combined rabeprazole amoxicillin, metronidazole treatment of duodenal ulcer and Helicobacter pylori （Hp） eradication efficacy. Method 80 cases of duodenal ulcer patients were randomly divided into two groups,40 cases of each group. The control group were treated with omeprazole ＋ amoxicillin ＋ metronidazole,observation group were treated with rabeprazole ＋ amoxicillin ＋ metronidazole. Efficacy and Hp eradication rate of the two groups were observed. Results The observation group treatment ld,7d remission rate were 75 % ,95 %, significantly higher than the control group 52. 5,77.5%, respectively （P 〈 0. 05 ）. Treatment efficiency, Hp eradication rate and incidence of adverse reactions of the two groups had no significant difference （P 〉 0. 05）. Conclusion Rabeprazole ＋ amoxicillin ＋ metronidazole triple therapy regimens for duodenal significant effect, onset time is short, high safety,worthy of promotion and application.

关 键 词：十二指肠溃疡 雷贝拉唑 三联疗法 HP根除率 

分 类 号：R573.1[医药卫生—消化系统]