Pharmacokinetics and tissue distributions of veratric acid after intravenous administration in rats  

作　　者：PENG Yu-Shuai LIU Li-Jia ZHAO Can YANG Xin LIU Chen WANG Ru-Feng 

机构地区：[1]School of Chinese Materia Medica,Beijing University of Chinese Medicine

出　　处：《Chinese Journal of Natural Medicines》2015年第7期535-539,共5页中国天然药物（英文版）

基　　金：supported by NSFC(Nos.81274044 and 81073018)

摘　　要：The present study was designed to investigate the pharmacokinetics and tissue distributions of veratric acid following intravenous administration in rats.The concentrations of veratric acid in rat plasma at various times after administrated at doses of 2.5,5,and 10 mg·kg–1 were quantified by HPLC.The tissue distributions of veratric acid at various times after a single intravenous dose of 2.5 mg·kg–1 were also analyzed.The plasma pharmacokinetic parameters at the three doses were as follows:t1/2,(86.23 ± 6.83),(72.66 ± 4.10) and(71.20 ± 2.90) min; C0,(11.10 ± 1.47),(23.67 ± 1.24) and(39.17 ± 3.90) μg·m L–1; and AUC0→∞,(1 240.90 ± 129.14),(2 273.84 ± 132.47) and(3 516.4 ± 403.37) min·μg·m L–1,respectively.The compound was distributed into tissues rapidly and extensively after intravenous administration and was mainly distributed into the liver,heart and kidneys.The present study was designed to investigate the pharmacokinetics and tissue distributions of veratric acid following intravenous administration in rats.The concentrations of veratric acid in rat plasma at various times after administrated at doses of 2.5,5,and 10 mg·kg^–1 were quantified by HPLC.The tissue distributions of veratric acid at various times after a single intravenous dose of 2.5 mg·kg^–1 were also analyzed.The plasma pharmacokinetic parameters at the three doses were as follows：t1/2,（86.23 ± 6.83）,（72.66 ± 4.10） and（71.20 ± 2.90） min; C0,（11.10 ± 1.47）,（23.67 ± 1.24） and（39.17 ± 3.90） μg·m L^–1; and AUC0→∞,（1 240.90 ± 129.14）,（2 273.84 ± 132.47） and（3 516.4 ± 403.37） min·μg·m L^–1,respectively.The compound was distributed into tissues rapidly and extensively after intravenous administration and was mainly distributed into the liver,heart and kidneys.

关 键 词：Veratric acid PHARMACOKINETICS Tissue distribution 

分 类 号：R969.1[医药卫生—药理学]