A new biflavone glucoside from the roots of Stellera chamaejasme  

作　　者：CHEN Wei LUO Xiao-Hua WANG Zhuo ZHANG Ying-Ying LIU Li-Ping WANG Hong-Bing 

机构地区：[1]School of Life Sciences and Technology,Tongji University

出　　处：《Chinese Journal of Natural Medicines》2015年第7期550-553,共4页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.81001369 and 31170327);the Fundamental Research Funds for the Central Universities(No.2000219078)of China

摘　　要：The present study investigated the chemical constituents of the roots of Stellera chamaejasme(Thymelaeaceae).One new biflavone glucoside(1),along with other thirteen known compounds(2–14),was isolated by repeated column chromatographic methods and their structures were elucidated on the basis of spectral analyses.The cytotoxic activities of selected compounds were evaluated against four human cancer cell lines(A549,BEL-7402,HCT-116,and MDA-MB-231) by the SRB assay method.Compound 9 showed remarkable cytotoxicity against BEL-7402 with IC50 value being 0.65 μg·mL-1; compounds 7,8,and 12 exhibited significant cytotoxic activity against A549 with IC50 values being 2.38,1.57,and 2.35 μg·m L-1,respectively.The present study investigated the chemical constituents of the roots of Stellera chamaejasme（Thymelaeaceae）.One new biflavone glucoside（1）,along with other thirteen known compounds（2–14）,was isolated by repeated column chromatographic methods and their structures were elucidated on the basis of spectral analyses.The cytotoxic activities of selected compounds were evaluated against four human cancer cell lines（A549,BEL-7402,HCT-116,and MDA-MB-231） by the SRB assay method.Compound 9 showed remarkable cytotoxicity against BEL-7402 with IC50 value being 0.65 μg·mL-1; compounds 7,8,and 12 exhibited significant cytotoxic activity against A549 with IC50 values being 2.38,1.57,and 2.35 μg·m L^-1,respectively.

关 键 词：Stellera chamaejasme THYMELAEACEAE Biflavone GLUCOSIDE CYTOTOXICITY 

分 类 号：R284[医药卫生—中药学]