感染科病房人苍白杆菌耐药性分析  

Drug resistance of Ochrobactrum anthropi isolated from patients of department of infectious disease

作　　者：郭玉香[1] 朱以军[1] 范顺富[1] 徐叶进[1] 吴平[1] 

机构地区：[1]金华市中心医院感染科,浙江金华321000

出　　处：《中华医院感染学杂志》2015年第14期3147-3149,共3页Chinese Journal of Nosocomiology

基　　金：浙江省卫生厅研究基金资助项目(00913-45)

摘　　要：目的探讨医院感染人苍白杆菌的分布特点及耐药性,为临床抗感染治疗提供依据。方法对2003年1月-2012年12月从感染科各类临床标本中分离到的26株人苍白杆菌相关资料进行统计分析。结果人苍白杆菌标本分布以血液标本为主占84.6%;人苍白杆菌对β-内酰胺类及酶抑制剂复合制剂抗菌药物的耐药率均>80.0%,但对碳青霉烯类、四环素类、喹诺酮类、氨基糖苷类抗菌药物的敏感性较高,敏感率从高到低依次为:美罗培南100.0%、米诺环素100.0%、左氧氟沙星96.2%、环丙沙星96.2%、亚胺培南92.3%、庆大霉素88.5%、妥布霉素84.6%。结论人苍白杆菌对β-内酰胺类抗菌药物的耐药性高,治疗可首选碳青霉烯类、四环素类、喹诺酮类或氨基糖苷类抗菌药物。OBJECTIVE To explore the distribution and drug resistance of Ochrobactrum anthropi causing nosocomial infections so as to provide guidance for clinical treatment of the infection.METHODS A total of 26 strains of O.anthropi were isolated from various clinical specimens that were obtained from the department of infectious disease from Jan 2003 to Dec 2012,then the related data of the isolated strains were statistically analyzed.RESULTS Of the isolated O.anthropi strains,84.6% were isolated from the blood specimens.The drug resistance rates of the O.anthropi toβ-lactams andβ-lactamase inhibitor compounds were more than 80.0%.However,the strains were highly susceptible to carbapenems,tetracyclines,quinolones,and aminoglycosides,and the drug susceptibility rates,in a descending order,were as follows：meropenem（100.0%）,minocycline（100.0%）,levofloxacin（96.2%）,ciprofloxacin（96.2%）,imipenem（92.3%）,gentamicin（88.5%）,and tobramycin（84.6%）.CONCLUSIONThe O.anthropi strains are highly resistant toβ-lactams antibiotics;the carbapenems,tetracyclines,quinolones,and aminoglycosides are the preferred antibiotics for the treatment.

关 键 词：人苍白杆菌 医院感染 感染科 耐药性 

分 类 号：R378[医药卫生—病原生物学]