卵巢子宫内膜异位症恶变与卵巢恶性肿瘤的关系及预后影响因素研究  

Ovaries of different disease progression and the relationship between the ovarian malignant tumor research to the state of survival

作　　者：陈玉花[1] 刘宇[1] 张福梅[1] 

机构地区：[1]陕西省延安市人民医院妇科,陕西延安716000

出　　处：《临床和实验医学杂志》2015年第14期1152-1154,共3页Journal of Clinical and Experimental Medicine

基　　金：陕西省教育厅科研计划项目(项目编号:01JK103)

摘　　要：目的探讨卵巢子宫内膜异位症恶变和卵巢恶性肿瘤之间的关系以及预后影响因素。方法回顾性分析2008年1月至2010年1月收治的原发性卵巢肿瘤80例患者为研究对象,按照是否卵巢子宫内膜异位症恶变将其分为卵巢子宫内膜异位症恶变组22例(观察组)和非卵巢子宫内膜异位症恶变组58例(对照组),比较两组患者一般临床特征及生存状况,观察两组之间的关系以及预后影响因素。结果两组患者在发病年龄、临床症状、CA125值、FIGO分期、肿块直径及组织学分型方面的差异具有统计学意义(P<0.05),而在化疗方案、化疗周期方面的差异无统计学意义(P>0.05),卵巢子宫内膜异位症恶变组患者的5年生存率高于非卵巢子宫内膜异位症恶变组,差异有统计学意义(P<0.05),COX多因素分析结果显示卵巢子宫内膜异位症恶变、FIGO分期、组织学分型是影响子宫内膜异位症患者预后的独立危险因素。结论卵巢子宫内膜异位症恶变是卵巢恶性肿瘤的危险因素,卵巢子宫内膜异位症恶变患者可能较其他卵巢恶性肿瘤患者拥有较好的预后,但要高度重视引发其恶变相关因素,做到防治结合,改善患者的预后。Objective To explore the ovaries different syndrome （ endometriosis, EMs） progression and the relationship between the ovar- ian malignant tumor and survival conditions. Methods A retrospective analysis of our hospital between January 2008 and January 2010 was performed. 80 patients with primary ovarian tumors were included as the research object. According to whether or not endometriosis caneerization, 80 cases of patients were divided into endometfiosis malignant transformation group （22 cases, observation group） and nonendometriosis malignant transformation group （58 cases, control group）. The clinical feature and living conditions of two groups were comparatively studied. Results There was significant difference between onset ages, clinical symptoms, CA125 values, FIGO stage, tumor diameter, histological classification of two groups （ P 〈 O. 05 ）, while no significant difference were found between chemotherapy regimens, cycles of chemotherapy （ P 〉 0. 05 ）. 5 - year survival rate of endometriosis malignant transformation group was significantly higher that of non - endometriosis malignant transformation group （ P 〈0.05）. COX multi -factor analysis results show that the ovaries of different disease progression, FIGO staging, and histological classifica- tion are independent risk factors affecting the prognosis. Conclusion Different disease progression in the ovary is a risk factor for ovarian malignant tumors. Different disease progression in patients with ovary may have better prognosis, but should attach great importance to trigger the factors associated with malignant transformation, to combine prevention and improve the prognosis of patients.

关 键 词：卵巢子宫内膜异位症 恶变 卵巢癌 预后 影响因素 

分 类 号：R737.31[医药卫生—肿瘤] R711.71[医药卫生—临床医学]