超选择性动脉溶栓并术后局部亚低温对急性脑梗死患者血清NSE和S-100蛋白的影响  

Effect of superselective intra-arterial thrombolysis combined with postoperative local mild hypothermia treatment on serum NSE and S-100 proteins in patients with acute cerebral infarction

作　　者：谷强 张津[2] 

机构地区：[1]北京市东城区第一人民医院内科,北京100075 [2]首都医科大学宣武医院神经内科,北京100053

出　　处：《临床和实验医学杂志》2015年第14期1179-1182,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的观察超选择性动脉溶栓及亚低温(MHT)治疗后,急性脑梗死(ACI)患者血清神经元特异性烯醇酶(NSE)和S-100β蛋白的变化。方法将74例ACI患者随机分为两组,观察组(40例)以超选择性动脉溶栓并术后MHT治疗,对照组(34例)只进行尿激酶静脉溶栓治疗。动态监测两组患者治疗前后血清NSE和S-100β蛋白含量。结果两组NSE和S-100β蛋白水平治疗前和治疗后1 d无显著性差异(P>0.05);治疗后3 d、7 d、14 d观察组均明显低于对照组(P<0.05)。结论超选择性动脉溶栓并术后亚低温治疗急性脑梗死能有效降低血清NSE和S-100β蛋白含量,对神经细胞形成保护。Objective To observe the effect of superselective intra - arterial thrombolysis combined with mild hypothermia treatment （MHT） on the changes of serum neuron specific enolase （NSE） and S- 10013 protein in acute cerebral infarction （ACI） patients. Methods Seventy - four cases of ACI were randomly divided into two groups, the observation group （40 cases） treated with superselective arterial thrombolysis and postoperative MHT, the control group （34 cases） treated with intravenous thrombolytic therapy with urokinase. Dynamic monitoring of serum NSE and S - 10013 protein content were conducted before and after the treatment in both groups. Results NSE and S - 10013 protein levels before and one day after treatment had no significant difference between two groups （ P 〉 0.05） ; but they were significantly lower in observation group on day 3, day 7 and day 14 after treatment than the control group （ P 〈 0.05 ）. Conclusion The treatment of superselective intra - arterial thrombolysis and postoperative MHT can effectively reduce serum NSE and S - 10013 levels and protect nerve ceils in ACI patients.

关 键 词：急性脑梗死 超选择性动脉溶栓 亚低温 神经元特异性烯醇化酶 S-100蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]