慢性荨麻疹过敏原检测的临床意义及可能的病因分析  

Study on the clinical significance of allergen testing in diagnosis of chronic urticaria and analysis of possible pathogens

作　　者：高广程[1] 许颖[2] 

机构地区：[1]首都医科大学附属北京友谊医院皮肤性病科,北京100050 [2]首都医科大学附属北京友谊医院检验科,北京100050

出　　处：《临床和实验医学杂志》2015年第14期1207-1210,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨过敏原检测对慢性荨麻疹诊疗的临床意义,同时分析慢性荨麻疹的可能致病因素。方法对临床确诊485例慢性荨麻诊患者采用德国Allergy Screen变应原定量免疫印迹法检测血清过敏原及总Ig E,检测血常规。对慢性荨麻诊可能的病因进行分析。结果 169例(34.85%)患者过敏原阳性;总Ig E水平>100 IU/ml者占241例(49.69%)。过敏原检出阳性率较低,慢性荨麻疹病因复杂,除外过敏原致敏外还有许多发病因素。结论开展过敏原检测在慢性荨麻疹诊治中的作用是有限的,病史的询问在寻找慢性荨麻疹的可能的原因或诱因中起重要作用。Objective To explore the clinical significance of allergen testing for chronic urticaria （ CU）, at the same time to discuss the possible pathogenic factors of CU. Methods The serum allergens and serum levels of total IgE of 485 patients with CU were detected by German allergy screen immunoblotting method. Some patients had taken blood routine examination. Review of literatures on causes of CU had also been carried out. Results The positive rate of tests was 34.85% （ 169 patients）. The total IgE level （ 〉 100 IU/mL） was positive in 241 patients （49.69%）. The positive rate of allergen test was low, and the etiology of CU was complex, There are many pathogenic factors besides the allergen sensitization. Conclusion The importance of detection of allergens for pathogenesis of CU is limited, and the history inquiries for searching the causes of CU may play an important role.

关 键 词：慢性荨麻诊 过敏原 IG E 免疫印迹 临床分型 病因分析 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]