喉鳞癌中三磷酸腺苷酶家族蛋白2、抗磷酸化致癌基因和张力蛋白同源的磷酸酶基因的表达及意义  

Expression and significance of ATAD2,C-MYC and PTEN in laryngeal squamous carcinoma

作　　者：朱赟 王小红[2] 

机构地区：[1]浙江省鄞州第二医院耳鼻咽喉科,浙江宁波315100 [2]浙江省肿瘤医院化疗中心,浙江杭州310022

出　　处：《中国医药导报》2015年第20期4-6,19,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(31370910)

摘　　要：目的检测喉鳞癌中三磷酸腺苷酶家族蛋白2（ATAD2）、抗磷酸化致癌基因（C—MYC）和张力蛋白同源的磷酸酶基因（PTEN）的表达，分析其临床价值。方法收集2012年3月-2014年2月经宁波市鄞州第二医院诊断并行喉鳞癌根治术的患者99例，选择术中留取的癌组织标本作为观察组，选择其中78例患者癌旁正常组织标本为对照组。采用免疫组化检测二组中ATAD2、C—MYC和PTEN的表达。结果观察组中ATAD2（63．64％比12．82％）和C—MYC（70．71％比16．67％）表达的阳性率明显高于对照组。PTEN的表达明显低于对照组（20．20％比82．50％），差异有高度统计学意义（P〈0．01）。观察组中ATAD2、C—MYC和PTEN表达的阳性率与肿瘤体积、淋巴结转移、脉管浸润和Ki67的表达有关（P〈0．05）。相关性分析显示观察组中ATAD2与C—MYC的表达呈正相关（r=0．43，P〈0．05），ATAD2与PTEN的表达呈负相关（r=～0．46，P〈0．05）。结论喉鳞癌组织中ATAD2、C—MYC高表达、PTEN低表达，对肿瘤的发生和进展有促进作用，ATAD2与C—MYC、PTEN可能具有一定的协同作用。Objective To detect the expressions of ATAD2, C-MYC and PTEN in laryngeal squamous carcinonma, analyze their clinical significance. Methods From March 2012 to February 2014, in Yinzhou Second Hospital, 99 patients diagnosed and underwent laryngeal squamous carcinoma radical prostatectomy were collected, intraoperative carcinoma tissue samples were selected as observation group, normal tissue adjacent to carcinoma samples of 78 cases from these laryngeal squamous carcinonma patients were selected as control group. Expressions of ATAD2, C-MYC and PTEN were detected by IHC methods in two groups. Results The positive rate of ATAD2 （63.64% vs 12.82%） and C-MYC （70.71% vs 16.67%） were in the observation group higher than those in control group, the positive rate of PTEN in the observation group were lower than that in control group （20.20% vs 82.50%）, the differences were statistically significant （P 〈 0.01）. The positive rate of ATAD2, C-MYC and PTEN were correlated with tumor size, lymph node metastasis, vascular invasion and Ki67 expression （P 〈 0.05）. In observation group, there was a positive relationship between ATAD2 and C-MYC （r = 0.43, P 〈 0.05）, and a negative relationship between ATAD2 and PTEN in observation group （r = -0.46, P 〈 0.05）. Conclusion The higher-expressions of ATAD2 and C-MYC, lower-expression of PTEN can promote occurrence and development in laryngeal squmous carcinoma. ATAD2 and C-MYC, ATAD2 and PTEN may have a syngergistic effect.

关 键 词：喉鳞癌 三磷酸腺苷酶家族蛋白2 抗磷酸化致癌基因 张力蛋白同源的磷酸酶基因 

分 类 号：R739.65[医药卫生—肿瘤]