多种血清标志物联合检测在诊断老年胃癌患者中的意义  

Meaning on variety of united detection serum markers in the diagnosis for elderly patients with gastric cancer

作　　者：杜娟[1] 席妍[1] 郑珂[1] 任既晨 王立波[1] 

机构地区：[1]吉林省肿瘤医院内二科,吉林长春130012

出　　处：《中国医药导报》2015年第20期16-19,共4页China Medical Herald

基　　金：吉林省卫生厅科技计划项目(2013ZC054)

摘　　要：目的探讨多种血清标志物联合检测在诊断老年胃癌患者中的意义。方法选择2012年11月～2014年10月于吉林省肿瘤医院诊治的老年（≥60岁）胃部疾病患者100例，其中胃癌患者40例（胃癌组）、萎缩性胃炎患者30例（萎缩性胃炎组）、浅表性胃炎患者30例（浅表性胃炎组）。采用酶联免疫吸附法（ELISA）定量检测血清PG（PCⅠ、PGⅡ）和Gas-17水平，采用化学发光法检测血清CEA、CA19—9及CA242水平。计算并比较血清PCⅠ、CEA、CA19—9及CA242单独检测和联合检测的灵敏度、特异度。结果三组患者血清PG（PGⅠ、PGⅡ）、Gas-17、CEA、CA19—9及CA242水平比较，差异有统计学意义（P〈0．05）。与浅表性胃炎组比较，胃癌组PGI降低（P〈0．05），PGⅡ、Gas-17、CEA、CA19—9及CA242水平均升高（P〈0．05）；与浅表性胃炎组比较，萎缩性胃炎组PGⅠ、Gas-17水平降低（p〈0．05），PGⅡ水平升高（P〈0．05）；与萎缩性胃炎组比较，胃癌组PGI水平降低（P〈0．05），Gas-17、CEA、CA19—9及CA242水平均升高（P〈0．05），PGⅡ水平虽有所增高，但差异无统计学意义（P〉0．05）。联合检测的灵敏度（67．5％，27／40）高于单独检测，差异有统计学意义（P〈0．05）。结论多种血清标志物联合检测有助于提高老年胃癌检出率，且联合检测优于单独检测。Objective To discuss the meaning on variety of joint detection serum markers in the diagnosis for elderly patients with gastric cancer. Methods From November 2012 to October 2014, in Tumor Hospital of Jilin Province, 100 elderly patients （60 years） with gastric disease were selected, 40 patients were gastric cancer （gastric cancer group）, 30 patients were atrophic gastritis （atrophic gastritis group）, 30 patients were superficial gastritis （superficial gastritis group）. PG （PG Ⅰ, PGⅡ ） and Gas-17 in serum were detected by ELISA. CEA, CA19-9 and CA242 were detected by chemiluminescence. The sensibility and specificity of single detection and united detection for PG Ⅰ , CEA, CA19-9 and CA242 were calculated and compared. Results PG （PG Ⅰ, PGⅡ）, Gas-17, CEA, CA19-9 and CA242 in serum of three groups were compared, the difference was statistically significant （P 〈 0.05）. Compared with superficial gastritis group, PG Ⅰ of gastric cancer group was lower （P 〈 0.05）, PG Ⅱ, Gas-17, CEA,CA19-9, CA242 of gastric cancer group were higher （P 〈 0.05）; PG Ⅰ , Gas-17 of atrophic gastritis group were lower （P 〈 0.05）, PG Ⅱ of atrophic gastritis group was higher （P 〈 0.05）. Compared with gastric cancer group, PG Ⅰ in gastric cancer group was lower （P 〈 0.05）, Gas-17, CEA, CA19-9, CA242 in gastric cancer group were higher （P 〈 0.05）, PG Ⅱ in gastric cancer group was higher, but there was no statistical difference （P 〉 0.05）. The sensibility of united detection （67.5%, 27/40） was higher than that of single detection, the difference was statistically significant （P 〈 0.05）. Conclusion The variety of united detection serum marker is helpful to diagnosis for elderly patients with gastric cancer, and united detection is better than single detection.

关 键 词：血清标志物 胃癌 萎缩性胃炎 胃蛋白酶原 胃泌素-17 

分 类 号：R735.2[医药卫生—肿瘤]