DNA甲基化与支气管哮喘  

DNA methylation and bronchial asthma

作　　者：徐礼[1] 向旭东[2] 

机构地区：[1]中南大学湘雅医学院附属肿瘤医院胸部内二科,长沙410000 [2]中南大学湘雅二医院呼吸内科,长沙410011

出　　处：《国际呼吸杂志》2015年第13期1008-1011,共4页International Journal of Respiration

摘　　要：支气管哮喘（简称哮喘）是一种气道慢性炎症性疾病，在哮喘的发病机制中，表观遗传学是联系环境因素与遗传易感因素之间的纽带，导致机体免疫系统的发育及功能紊乱，从而促进哮喘的发生。DNA甲基化作为最常见的表观遗传修饰形式，食物与环境因素通过DNA甲基化产生对哮喘细胞学组分CD4＋T细胞分化的影响。母体产前食用富含甲基供体饮食，吸入环境中的危险因子均可影响CD4＋T细胞在体内的DNA甲基化，导致“Th2极化”，促进哮喘的发生。Bronchial asthma （asthma） is a chronic inflammatory disease of the airways. In the pathogenesis of asthma,epigenetics links the environmental factors and genetic susceptibility,interrupting the differentiation and function of the immune system, thus contributing to the occurrence of asthma. DNA methylation is known as the most common form of epigenetics. Food and environmental factors affect the differentiation of CD4＋ T cells among the cellular components of asthma by DNA methylation. Maternal prenatal consumption of diet rich in methyl donors, and inhalation of risk factors in the environment can affect DNA methylation in CD4＋ T cells in vivo,resulting in ＂Th2 polarization＂ and promoting the disease of asthma.

关 键 词：哮喘 表观遗传学 DNA甲基化 CD4+T细胞 

分 类 号：R730.231[医药卫生—肿瘤]