某三级甲等综合医院奇异变形菌感染调查研究  

Research of infections of Proteus mirabilis in a class-A teaching hospital

作　　者：胡业佳[1] 姜海明[2] 张晓丽[3] 崔勇[1] 

机构地区：[1]滨州医学院基础学院,山东烟台264003 [2]滨州医学院附属医院急诊科,山东滨州256603 [3]滨州医学院护理学院,山东烟台264003

出　　处：《中华医院感染学杂志》2015年第13期2909-2911,共3页Chinese Journal of Nosocomiology

基　　金：山东省高等学院科技计划基金资助项目(J13LK15);山东省高等教育规划基金资助项目(YJKT201317)

摘　　要：目的：分析某三级甲等综合医院奇异变形菌感染情况，为采取预防措施降低奇异变形菌感染提供可靠依据。方法调查某三级甲等综合医院2010－2012年174207例住院患者临床资料，对发生奇异变形菌感染患者送检各类标本进行培养及耐药性分析，并对监测结果采用SPSS16．0软件进行统计分析。结果3年住院患者共发生奇异变形菌感染147例，感染率0．08％；其中2010年住院患者48852例，发生奇异变形菌感染40例，感染率为0．08％，2011年住院患者58573例，发生奇异变形菌感染48例，感染率为0．08％，2012年住院患者66782例，发生奇异变形菌感染59例，感染率为0．09％；不同送检标本中检测到的奇异变形菌数量不同，其中痰液中检测到的菌株数最多，占50．34％，其次为脓液占14．29％、分泌物占9．52％；不同科室奇异变形菌分布不同，其中重症监护病房所占比例最高为24．50％，其次为神经外科为19．74％；不同年龄奇异变形菌感染率不同，其中50～60岁发生率最高，占17．01％，其次为70～80岁占16．33％、60～70岁占15．65％；奇异变形菌对美罗培南、头孢哌酮／舒巴坦、哌拉西林／他唑巴坦、亚胺培南等较敏感，对四环素、磺胺甲噁唑／甲氧苄啶、替卡西林、氨苄西林、头孢唑林等耐药性较高。结论应针对高发科室、高发年龄采取针对性措施，根据药敏结果合理选择抗菌药物，降低奇异变形菌感染发生率。OBJECTIVE To analyze the condition of Proteus mirabilis infections in a class‐A hospital so as to pro‐vide basis for preventive measures to decrease P .mirabilis infection rate .METHODS The clinical data of 174207 cases of patients hospitalized from 2010 to 2012 in a class‐A hospital were investigated .And the samples isolated from patients infected by P .mirabilis were cultivated and drug resistance analysis was conducted .The results were statistically analyzed by SPSS 16 .0 software .RESULTS In 174 ,207 cases of patients hospitalized from 2010 to 2012 ,147 stains of P .mirabilis were detected ,in which 40 ones were from 48 ,852 cases who were admitted in the hospital in 2010 with detection rate of 0 .08 ‰ ,and 48 ones were from 58 ,573 cases in 2011 with detection rate of 0 .08 ‰ ,and 59 ones were from 66 ,782 cases in 2012 with detection rate of 0 .09 ‰ .The numbers of P .mira‐bilis were different in different samples ,of which the largest was in sputum ,accounting for 50 .34% ,followed by pus （14 .29% ） and secretions （9 .52% ） .The distribution of P .mirabilis in different departments was different , of which the highest was of ICU （24 .50% ） ,followed by neurosurgery （19 .74% ） .P .mirabilis infection rate was different in various age groups ,of which the highest was of 50 to 60 years old patients ,accounting for 17 .01% , followed by those of 70 to 80 years old （16 .33% ） ,and 60 to 70 （15 .65% ） .P .mirabilis were more sensitive to meropenem ,cefoperazone/sulbactam ,piperacillin/tazobactam and lmipenem ,but were more resistant to tetracy‐cline ,sulfamethoxazole ,ticarcillin ,ampicillin and cefazolin .CONCLUSION Specific measures should be taken to high‐risk ages or departments with high incidence ,and to make a reasonable choice of antibiotics based on suscep‐tibility results so as to reduce the incidence rate of P .mirabilis infections .

关 键 词：医院感染 奇异变形菌 耐药性 

分 类 号：R378[医药卫生—病原生物学]