桦褐孔菌醇对人卵巢癌裸鼠移植瘤的抑制作用  

Inhibiting effect of inotodiol on transplantation tumor of human ovarian cancer in nude mice

作　　者：钟秀宏[1] 赵芬琴[2] 高宇[3] 赵丽微[1] 杨宁江[4] 

机构地区：[1]吉林医药学院病理教研室,吉林吉林132013 [2]河南大学药学院 [3]吉林大学中日联谊医院 [4]吉林医药学院附属医院

出　　处：《中国妇幼保健》2015年第20期3351-3353,共3页Maternal and Child Health Care of China

基　　金：吉林省自然科学基金项目〔201215226〕;吉林省卫生厅项目〔2011z062〕

摘　　要：目的观察桦褐孔菌醇(Inotodiol)对人卵巢癌裸鼠移植瘤的抑制作用。方法建立卵巢癌SKOV3裸鼠移植瘤模型,将30只荷瘤鼠随机分为空白对照组、桦褐孔菌醇高、中、低浓度组和顺铂(DDP)组各6只。桦褐孔菌醇组予桦褐孔菌醇腹腔注射治疗,DDP组予DDP注射治疗,空白对照组予生理盐水腹腔注射治疗。连续治疗3周后观察疗效并记录各组裸鼠及其皮下移植瘤生长情况,绘制肿瘤生长曲线和肿瘤生长抑制率。结果桦褐孔菌醇组对移植瘤有明显的抑瘤作用,桦褐孔菌醇高、中、低浓度组抑瘤率为43.10%、28.73%和13.53%,与空白对照组比较差异有统计学意义(P<0.05);高剂量组抑瘤率与顺铂组差异无统计学意义(P>0.05)。结论桦褐孔菌醇对人卵巢癌裸鼠移植瘤具有抑制作用。Objective：To observe the inhibiting effect of inotodiol on transplantation tumor of human ovarian cancer in nude mice.Methods：Transplantation tumor of ovarian cancer SKOV3 cell line mouse model was established,30 nude mice with transplanted SKOV3 tumor were randomly divided into blank control group,high-dose inotodiol group,middle-dose inotodiol group,low-dose inotodiol group,and DDP group,6 mice in each group.The mice in three inotodiol groups were treated with intraperitoneal injection of inotodiol; the mice in DDP group were treated with injection of DDP; the mice in blank control group were treated with intraperitoneal injection of normal saline.After consecutive treatment for 3 weeks,the curative effects in five groups were observed,the growth of transplantation tumor were recorded;tumor growth curve and inhibition rate were drawn.Results：Inotodiol had significant inhibiting effect on transplantation tumor; the inhibition rates in high-dose inotodiol group,middle-dose inotodiol group,low-dose inotodiol group were 43.10%,28.73%,and 13.53%,respectively,compared with blank control group,there were statistically significant differences（P〈0.05）; there was no statistically significant difference between high-dose inotodiol group and DDP group（P〈0.05）.Conclusion：Inotodiol has inhibiting effect on growth of transplantation tumor of human ovarian cancer in nude mice.

关 键 词：桦褐孔菌醇 裸鼠 卵巢癌 抑制 

分 类 号：R731[医药卫生—肿瘤]