多肽mPEG-SC_(20k)-HM-3联合奥沙利铂对人肝癌细胞SMMC-7721裸鼠移植瘤的抑制作用  

Antitumor effect of peptide m PEG-SC_(20k)-HM-3 and oxaliplatin combination against human hepatocellular carcinoma SMMC-7721 in nude mice

作　　者：何俊劲 王佳艺[1] 郝静超 程昊冉 徐寒梅[1] 

机构地区：[1]中国药科大学多肽药物创制工程研究中心,南京210009

出　　处：《中国药科大学学报》2015年第4期476-480,共5页Journal of China Pharmaceutical University

基　　金：国家高技术研究发展计划(863计划)资助项目(No.2012AA020304);国家"重大新药创制"科技重大专项资助项目(No.2014ZX09508007-001;No.2012ZX09103301-004)~~

摘　　要：m PEG-SC20k-HM-3是具有整合素亲和性的一种新型高效血管生成抑制多肽,为探索其与传统化疗药物联用的抗肿瘤活性,建立人肝癌细胞SMMC-7721裸鼠移植瘤模型,选用奥沙利铂为化疗药物,根据临床前抗肿瘤药效学方法评价联合用药的抑瘤作用,并用金氏公式判断两种药物的联合作用。结果显示,与单独用药相比,联合用药组的抑瘤效果更好,且均具有显著差异(P<0.05)。其中,奥沙利铂(7.5 mg/kg)联合m PEG-SC20k-HM-3(73.4 mg/kg)的肿瘤抑制率为84.6%,抑制作用比单用奥沙利铂(7.5 mg/kg)和单用m PEG-SC20k-HM-3(73.4 mg/kg)均有显著提高。根据金氏公式计算,其Q值为1.164(>1.15),可判定该组的用药组合表现出协同作用。结果表明,m PEG-SC20k-HM-3与奥沙利铂单独给药均能抑制肿瘤生长,两者联用对肝细胞癌具有协同作用。mPEG-SC20k-HM-3 is a novel anti-angiogenesis peptide with integrin affinity. To investigate the anti- tumor activities of mPEG-SC20k-HM-3 and oxaliplatin （OXA） combination, a transplanted tumor model of human hepatocellular carcinoma SMMC-7721 in nude mice was established. Jin＇s formula to evaluate the combination effect was used. Data suggested that the anti-tumor activities of combined groups were better than those of single drug （ P 〈0. 05）. Inhibition rate of group 8（ OXA 7.5 mg/kg and mPEG-SC2oK-HM-3 73.4 mg/kg） was 84. 6%, which showed remarkable superiority to group 3 （ OXA 7.5 mg/kg） and group 4 （ mPEG-SC20k-HM-3 73.4 mg/kg）. The Q of group 8 was 1. 164（ 〉 1.15）. This combination had synergistic effect. Combination of mPEG- SC2ok-HM-3 and oxaliplatin is a method of inhibiting hepatocellular carcinoma.

关 键 词：多肽 mPEG—SC20k-HM-3 肝细胞癌 抗肿瘤血管生成 奥沙利铂 联合用药 裸鼠移植瘤 

分 类 号：R96[医药卫生—药理学]