结直肠癌组织中ERCCl、Survivin的表达及临床意义  

Expression of ERCC1 and Survivin in colorectal carcinoma and its clinical significance

作　　者：黄勇[1] 伦增军[1] 鲍广建[1] 钟显峰 褚朋[1] 

机构地区：[1]山东省枣庄市立医院外二科,277100

出　　处：《中国实用医刊》2015年第14期62-65,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨核苷酸切除修复交叉互补基因l（ERCCl）及生存素（Survivin）在结直肠癌中的表达及其临床意义。方法采用免疫组织化学法检测82例结直肠癌组织中ERCCl、Survivin表达水平，观察其与临床病理特征的关系。结果ERCCl在结直肠癌组织表达水平（26．632±5．145）显著低于正常结直肠组织（39．709±4．639）．Survivin在结直肠癌组织表达水平（38．729±6．341）显著高于正常结直肠组织（17．759±1．776）。结直肠癌组织中ERCCl表达与组织病理学分级有关，但与结直肠癌的性别、年龄、TNM分期、淋巴结转移无关，Survivin表达与TNM分期、淋巴结转移有关，但与结直肠癌的性别、年龄、组织病理学分级无关。结直肠癌组织中ERCCl、Sur-vivin表达无相关性（r=0．147，P=0．189）。ERCCl或Survivin蛋白阴性表达患者生存期均明显长于ERCCl或Sur-vivin蛋白阳性表达者，ERCCl和Survivin双阴性表达患者生存期亦明显长于两者双阳性表达者。结论联合检测ERCCl和Survivin的表达将有助于判断结直肠癌的转移潜能及预后。Objective To investigate the expression of excision repair cross complementing gene 1 （ ERCC1 ） and Survivin expression in colorectal carcinoma and its clinical significance. Methods ERCC1 and Survivin expres- sions in 82 cases of colorectal carcinoma tissues were measured by immunohistochemistry. Correlations between the expression of ERCC1 and Survivin and clinic-pathological characteristics in eolorectal carcinoma were analyzed. Re- suits The expression of ERCC1 in coIorectal carcinoma tissues （26. 632 ± 5. 145） was significantly lower than that in normal colorectal tissues （39. 709 ± 4. 639 ） , the expression of Survivin in colorectal carcinoma tissues （38. 729 ± 6. 341 ） was significantly higher than that in normal colorectal tissues（ 17. 759 ± 1. 776）. The expression of ERCC1 in colorectal carcinoma tissues was significantly correlated with histologic grade, but was not correlated with gender, age, TNM stage, lymph node metastasis. The expression of Survivin in colorectal carcinoma tissues was significantly correlated with TNM stage and lymph node metastasis, but was not correlated with gender, age, histologic grade. No evidence was found that the expression of ERCC1 was correlated with the expression of Survivin in colorectal carcinoma tissues （r = 0. 147, P = 0. 189）. Compared with patients with positive ERCC1 or Survivin expression, patients with negative ERCC1 or Survivin expression had significantly longer mean survival. Patients with ERCC1 and Survivin double negative expression also had significantly longer mean survival than that with ERCC1 and Survivin double positive expres- sion. Conclusions Detection of the expressions of ERCC1 and Survivin can estimate the metastatic potential and predict the prognosis for colorectal carcinoma.

关 键 词：核苷酸切除修复交叉互补基因1 生存素 结直肠癌 免疫组织化学法 预后 

分 类 号：R734.201[医药卫生—肿瘤]