功能性消化不良脾虚证动物模型的制作及评价  

Reconstruction and assessment of functional dyspepsia with spleen deficiency in TCM

作　　者：刘晶[1] 李峰[1] 唐旭东[2] 马捷[1] 葛东宇[1] 李根茂[1] 刘燕[1] 刘艳阳[1] 韩晨霞[1] 吴卓耘 

机构地区：[1]北京中医药大学基础医学院 [2]中国中医科学院西苑医院消化内科

出　　处：《环球中医药》2015年第6期701-705,共5页Global Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)(2013CB531703)

摘　　要：目的复制并评价功能性消化不良脾虚证动物模型。方法运用碘乙酰胺复合小平台劳倦因素造模法,制作功能性消化不良脾虚证动物模型,并观察动物一般状态、体重、饮食情况及胃病理改变,运用糖水偏好试验,球囊试验对功能性消化不良脾虚证进行评价。结果碘乙酰胺及复合小平台大鼠,均出现饮食减少,糖水偏好降低,胃敏感性增高。但碘乙酰胺复合小平台组大鼠体重下降明显,并伴有倦怠等精神症状。结论模型符合功能性消化不良脾虚证标准,但碘乙酰胺复合小平台组脾虚证表征更加明显。Objective Reconstruction and assessment of animal model of function dyspepsia with spleen deficiency in TCM. Methods Animal model was reconstructed by transient neonatal gastric irritation with iodoacetamide（ IA） oral gavages and modified multiple platform method. Appearance,bodyweight,quantity of food and water in-take,sucrose preference,and gastric hypersensitivity were observed to assess whether it is the model of functional dyspepsia with spleen deficiency. Results The IA and IA with modified multiple platform method models all had less food and water in-take,low sucrose preference,and gastric hypersensitivity. The rats of IA with modified multiple platform method got lower body weight and more fatigue. Conclusion Both models met the standards of functional dyspepsia with spleen deficiency,however,IA with modified multiple platform method model appeared more spleen deficiency-like behavioral.

关 键 词：功能性消化不良 脾虚证 动物模型 

分 类 号：R-332[医药卫生]