消栓肠溶胶囊对气虚血瘀症缺血性中风后炎症反应的影响及神经保护作用的研究  

Influence of Xiaoshuan Enteric- coated Capsule to Inflammatory Response and Neuroprotection in Patients of Cerebral Ischemic Stroke of Qi Deficiency and Blood Stasis Type

作　　者：俞建洪 查渭 叶关胜 方央 沈红枫 傅苏娜 孙奇华 

机构地区：[1]绍兴市立医院老年科,浙江绍兴312000

出　　处：《中华中医药学刊》2015年第7期1646-1649,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省医药卫生科技计划项目(2011KYA145)

摘　　要：目的:探讨消栓肠溶胶囊治疗气虚血瘀症缺血性中风的临床疗效,及其对患者神经保护作用和炎症反应,阐明其作用机制。方法:70例气虚血瘀症缺血性中风患者随机分为治疗组和对照组。对照组给予常规治疗,治疗组采用常规治疗联合消栓肠溶胶囊治疗,治疗前和治疗后对患者的神经功能缺损情况和日常生活活动能力进行评估,检测血清TNF-ɑ和IL-6和IL-8水平,疗程结束后评价临床疗效,记录不良反应。结果:治疗后两组神经功能缺损程度评分与治疗前比较均明显下降,且治疗组与对照组比较显著降低(t=9.271,P<0.01)。治疗组神经功能疗效有效率为91.4%,对照组为65.7%,治疗组临床疗效有效率显著高于对照组(χ2=6.873,P<0.01);治疗组中医症候疗效有效率为94.3%,显著高于对照组(74.3%),两组临床疗效有效率比较有显著性差异(χ2=5.285,P<0.05)。治疗后两组炎症因子TNF-ɑ、IL-6、IL-8水平与治疗前比较均明显下降,且治疗组与对照组比较显著降低(t=6.454、5.761、7.570,P<0.01)。两组均末见明显不良反应。结论:消栓肠溶胶囊治疗气虚血瘀症缺血性中风,能有效地提高临床疗效,改善神经功能,且安全可靠,其机制可能是通过减少炎症因子TNF-ɑ、IL-6、IL-8的分泌与释放,从而抑制炎症的发生与发展来实现的。Objective：To investigate the clinical efficacy and influence of inflammatory response and neuroprotection with Xiaoshuan enteric - coated capsule in patients cerebral isehemie stroke of qi deficiency and blood stasis type, and e- lucidate its mechanism of action. Methods ：70 cases of patients with cerebral ischemic stroke of qi deficiency and blood stasis type were randomly divided into treatment group and control group. The control group＇s patients were given conven- tional treatment, and the treatment group＇s patients were given the treatment of conventional treatment combined with Xi- aoshuan enteric - coated capsule. The clinical efficacy, neurological deficit situation, activities of daily living and adverse reactions were evaluated at the end of treatment and the serum TNF - ct, IL - 6 and IL - 8 levels were detected. Results ： After treatment, the neurological deficit scores of the two groups were reduced and when the treatment group compared with control group, the difference was significant （ t = 9.271, P 〈 0.01 ）. The neurological effective rate of the treatment group was 91.4% and it was significantly higher than that of the control group （65.7%）. Compared with the control group ,the difference was significant （ X2 = 6. 873 ,P 〈 0.01 ）. The TCM symptoms effective rate of the treatment group was 94.3% and it was significantly higher than that of the control group （74.3%）. Compared with the control group, the difference was significant （ ~z = 5. 285, P 〈 0.05 ）. After treatment, the inflammatory eytokines TNF - a, IL - 6 and IL - 8 levels of two groups were significantly decreased and the levels of treatment group were significantly lower than that of the control group（ t = 6. 454,5. 761 and 7. 570 ,P 〈0.01 ）. There were no serious adverse reactions in the two groups. Conclu- sion ： It is safe and reliable that Xiaoshuan enteric - coated capsule treating the patients cerebral ischemie stroke of qi defi- ciency and blood stasis type. It can effectively improve t

关 键 词：缺血性中风 气虚血瘀症 消栓肠溶胶囊 神经功能 炎症反应 临床疗效 

分 类 号：R743.33[医药卫生—神经病学与精神病学]