地黄饮子胶囊联合盐酸多奈哌齐片治疗血管性痴呆临床观察  

Dihuang Yinzi Capsule Combined with Denepezil in Treatment of Vascular Dementia

作　　者：李诗国[1] 戴圣伟[1] 李群伟[1] 

机构地区：[1]浙江省丽水市中医院综合内科,丽水323000

出　　处：《浙江中西医结合杂志》2015年第7期632-634,643,共4页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察地黄饮子胶囊联合盐酸多奈哌齐片治疗血管性痴呆肾精亏虚兼痰瘀阻络证患者的临床疗效。方法将110例血管性痴呆肾精亏虚兼痰瘀阻络证患者随机分为观察组57例与对照组53例,对照组给予盐酸多奈哌齐片,每次5-10mg,1天1次口服。观察组在对照组基础上加用地黄饮子胶囊,每次2g,1天2次口服。两组均以30天为1个疗程,治疗6个疗程。两组于治疗前后采用简易精神状态检查表（MMSE）评价患者认知功能,采用Blessed行为量表（BBS评分）评价患者行为能力,采用中医症状积分量表评价临床疗效。结果观察组中医症状总有效率75.44%,对照组为58.59%,两组比较差异有统计学意义（P〈0.05）。治疗后两组MMSE评分升高[观察组MMSE总分：（22.40±3.99）分比（16.60±3.89）分,记忆力：（4.66±1.49）分比（3.11±0.89）分,定向力：（8.07±2.22）分比（6.57±2.01）分,计算力和注意力：（3.26±1.05）分比（1.91±0.78）分,语言理解：（6.94±1.80）分比（5.06±1.60）分;对照组MMSE总分：（19.88±3.95）分比（16.52±3.38）分,记忆力：（3.95±1.24）分比（3.12±0.95）分,定向力：（7.44±2.15）分比（6.55±1.97）分,计算力和注意力：（2.67±0.88）分比（1.88±0.89）分,语言理解：（6.04±1.70）分比（5.01±1.61）分;P〈0.05,P〈0.01）];两组治疗后各项比较,差异有统计学意义（P〈0.05）。治疗后两组BBS评分及中医症状积分降低[观察组BBS总分：（14.47±3.69）分比（19.67±4.25）分,日常生活能力：（6.27±3.31）分比（8.98±3.42）分,习惯：（4.25±1.96）分比（6.51±2.24）分,个性：（3.12±1.61）分比（4.73±1.82）分,中医症状积分：（12.10±3.48）分比（20.03±4.72）分;对照组BBS总分：（16.81±3.28）分比（19.72±3.98）分,日常生活能力：（7.67±3.21）分比（8.84±3.02）分,习惯：（4.89±1.95）分比（6.76±2.05）分,个性：（3.92±1.02）分比（4.86±1.Objective To investigate the clinical effect of Dihuang Yinzi capsule combined with denepezil in treatment of vascular dementia with TCM differentiated symptoms of the kidney-essence deficiency and phlegm-stasis obstructing network vessels.Methods A total of 110 vascular dementia patients with the pattern of the kidney-essence deficiency and phlegm-stasis obstructing network vessels were randomized into observation group（n=57）and control group（n=53）.Control group received 5-10 mg denepezil once daily.Observation group was given 2mg Dihuang Yinzi capsule twice daily in addition to denepezil therapy.The treatment course lasted for 6 months,then the therapeutic effect was assessed by TCM Symptom Score Scale and the cognitive function and behavior ability of patients were evaluated by Mini-mental State Examination（MMSE） and Blessed Dementia Score（BDS）,respectively.Results The total efficacy of TCM syndrome in observation and control groups was 75.44% and 58.59%,respectively,with a significant difference between them（P〈0.05）.In MMSE,the total score and scores of Recall,Orientation,Attention and Calculation,Language and Praxis were significantly increased after treatment both in two groups（observation group：22.40±3.99 vs 16.60±3.89,4.66±1.49 vs 3.11±0.89,8.07±2.22 vs 6.57±2.01,3.26±1.05 vs1.91±0.78,6.94±1.80 vs 5.06±1.60; control group：19.88±3.95 vs 16.52±3.38,3.95±1.24 vs 3.12±0.95,7.44±2.15 vs6.55 ±1.97,2.67 ±0.88 vs 1.88 ±0.89,6.04 ±1.70 vs 5.01 ±1.61; allP〈0.05,P 0.01） and significant differences in scores were found between two groups after treatment（P〈0.05）.In BDS,the total score and scores of everyday activities,habits,and personality were decreased after treatment in both groups（observation group：14.47 ±3.69 vs19.67±4.25,6.27±3.31 vs 8.98±3.42,4.25±1.96 vs 6.51±2.24,3.12±1.61 vs 4.73±1.82; control group：16.81±3.28 vs19.72±3.98,7.67±3.21 vs 8.84±3.02,4.89±1.95 vs 6.76±2.05,3.92±1.02 vs 4.86±1.42; all P〈0.05） and significant diffe

关 键 词：血管性痴呆 肾精亏虚兼痰瘀阻络 盐酸多奈哌齐片 

分 类 号：R749.13[医药卫生—神经病学与精神病学]