家蚕——新的内分泌干扰物筛选靶标  

Silkworm——A New Target for Endocrine Disrupting Chemicals Screening

作　　者：沈卫锋[1] 孟智启[1] 蔡磊明[2] 

机构地区：[1]浙江省农业科学院蚕桑研究所,杭州310021 [2]浙江省农业科学院农产品质量标准研究所,杭州310021

出　　处：《生态毒理学报》2015年第2期154-158,共5页Asian Journal of Ecotoxicology

基　　金：浙江省重点科技创新团队项目(2011R50028-4);农业部农药残留检测重点实验室项目(2013PRG03)

摘　　要：内分泌干扰物对人类及环境的影响日益严重,如何建立快速有效的筛选方法,从复杂的周围环境中鉴别出具有内分泌干扰活性的物质,指导人们尽量规避不必要的暴露风险,成了当前环境学家的重要任务。本文以鳞翅目昆虫的模式物种家蚕为对象,介绍了其内分泌系统组成及相关激素的作用,分析了作为内分泌干扰物筛选靶标的优势,阐述了候选的测试端点及依据,从理论和方法不同角度探讨了家蚕成为一种新的内分泌干扰物筛选靶标的可行性。The influence of endocrine disrupting-chemicals （EDCs） on human and environment is becoming more and more serious. The challenging tasks for environmental experts are establishing an efficient and rapid screening method to identify the active EDCs from complex environment,and guiding people to avoid unnecessary exposure risk. The article introduces the composition of endocrine system and their associated hormones of silkworm （bombyx mori）. The advantages of silkworm as an ideal candidate for testing EDCs and candidate measurement endpoints are detailed analysis. The feasibility of silkworm as a new EDC test species are also discussed from the perspective of theory and methods.

关 键 词：内分泌干扰物 家蚕 筛选靶标 

分 类 号：X171.5[环境科学与工程—环境科学]