食欲素A与脑血管疾病  

Orexin A and cerebrovascular diseases

作　　者：何薇[1] 苏志强[1] 

机构地区：[1]哈尔滨医科大学附属第一医院神经内科,150006

出　　处：《国际脑血管病杂志》2015年第5期374-377,共4页International Journal of Cerebrovascular Diseases

摘　　要：食欲素（orexin）是一类下丘脑的重要神经肽，包括A和B2种。食欲素与许多生理功能有关，包括睡眠－觉醒、能量平衡、内分泌、内脏功能等，并且与一些病理生理学变化也有一定关系，如嗜睡、药物滥用等。近年来，有关食欲素在脑血管病中的病理生理学作用及其机制和临床意义日益引起关注。文章概述了食欲素的作用，重点阐述食欲素A在脑血管病中的作用。Orexins are a class of important hypothalamic neuropeptides,including type A and B. Orexins are associated with numerous physiological functions, including sleep-aw akening, energy balance, endocrine and visceral functions, and they also have certain relations with the pathophysiological changes, such as drow siness and drug abuse. In recent years, the pathophysiological role and mechanism, as well as the clinical significance of orexins in cerebrovascular diseases are causing concern. This article summarizes the roles of orexins and focuses on the roles of orexin A in cerebrovascular diseases.

关 键 词：食欲素 食欲素受体 卒中 脑缺血 脑出血 蛛网膜下腔出血 

分 类 号：R743[医药卫生—神经病学与精神病学]