阿司匹林联合氯吡格雷治疗大脑中动脉狭窄脑梗死的临床疗效及安全性分析  

The clinical efficacy and safety of aspirin combined with clopidogrel in the treatment of middle cerebral artery stenosis in cerebral infarction

作　　者：李镇煌[1] 薛永全[1] 杨丹[1] 李鹤[1] 

机构地区：[1]吉林省敦化市医院,吉林敦化133700

出　　处：《转化医学电子杂志》2015年第5期37-38,共2页E-Journal of Translational Medicine

摘　　要：目的:探讨阿司匹林联合氯吡格雷治疗大脑中动脉狭窄脑梗死的临床疗效.方法:选取我院收治的80例大脑中动脉狭窄脑梗死患者为研究对象,随机分组,对照组单用阿司匹林进行治疗,实验组在对照组的基础上增加氯吡格雷进行治疗.对两组患者的临床疗效进行观察和比较.结果:实验组的改良Fugl-Meyer上肢体综合功能评分、改良Barthel指数以及NIHSS评分改善情况明显优于对照组,在脑梗死进展率、复发率比较上,实验组比对照组低,差异明显,有统计学意义(P<0.05).两组患者均无明显出血.结论:采用阿司匹林联合氯吡格雷对大脑中动脉狭窄脑梗死进行治疗,安全可靠,疗效理想,值得普及和应用.AIM： To investigate and analyze the clinical efficacy of aspirin combined with clopidogrel in the treatment of middle cerebral artery stenosis in cerebral infarction. METHODS： 60 cases of middle cerebral artery stenosis in patients with cerebral infarction admitted in our hospital from January 2014 to January 2015 were randomly divided into control group and experimental group, 30 cases in each. The control group was given aspirin treatment, the experimental group increased clopidogrel therapy. Observe and compare the patient outcomes of two groups. RE- SULTS： The experimental group is dramatically higher than con- trol group in total effective rate with significant difference （P 〈 0.05）. The NIHSS score and Barthel index of experimental group post-treatment is dramatically higher than control group with significant difference （P 〈 0.05 ）. No severe side effects were observed in both groups. CONCLUSION： The treatment of aspirin combined with clopidogrel for patients with middle cerebral artery stenosis in cerebral infarction has high safety and can effectively improve the patient＇s condition and symptoms, being worthy of popularizing application in clinical.

关 键 词：阿司匹林 氯吡格雷 大脑中动脉狭窄脑梗死 临床疗效 

分 类 号：R743.32[医药卫生—神经病学与精神病学]