肌钙蛋白和脑钠肽在蒽环类药物致心脏毒性中的预测价值  

The Value of Troponin Ⅰ and Brain Natriuretic Peptide in Cardiac Toxicity Caused by Anthracyclines

作　　者：谷文龙[1] 赵明宏[1] 颜廷华[1] 孙军[1] 袁琳[1] 

机构地区：[1]南通大学附属建湖医院,江苏建湖224700

出　　处：《中国肿瘤》2015年第7期618-620,共3页China Cancer

基　　金：盐城市医学科技发展计划项目(YK2012084)

摘　　要：[目的]探讨肌钙蛋白Ⅰ和脑钠肽评估蒽环类药物对心脏的早期毒性的价值。[方法]对2013年3月至2014年10月收治50例肿瘤患者,化疗方案以静脉滴注表阿霉素为主,表阿霉素总累积量300±75mg/m2,于化疗前及化疗结束后检测血浆肌钙蛋白Ⅰ和脑钠肽含量。[结果 ]全组患者中发生心脏毒性8例,发生心脏毒性患者化疗前肌钙蛋白Ⅰ和脑钠肽水平均无心脏毒性组升高,且具有统计学意义(P<0.05)。[结论]在监测表阿霉素心脏毒性上,肌钙蛋白Ⅰ和脑钠肽能较早期反映心脏损害。[Purpose] To investigate the value of troponin Ⅰ（CTn） and brain natriuretic peptide（BNP）in assessing early cardiac toxicity caused by anthracyclines. [Methods] A total of 50 patients with cancer were treated with epirubicin for six chemotherapy courses with an accumulation dosage of300±75mg/m2 from March,2013 to October,2014. The levels of CTn and BNP were detected before and after chemotherapy.[Results] Eight cases occurred cardiac toxicity. The levels of CTn and BNP at pre-chemotherapy in patients with cardiac toxicity were higher than those with no cardiac toxicity with significant difference（P〈0.05）. [Conclusion] CTn and BNP can predicate the cardiac damage caused by anthracycline in early stage.

关 键 词：蒽环类药物 心脏毒性 脑钠肽 肌钙蛋白Ⅰ 

分 类 号：R730.53[医药卫生—肿瘤]