环境低硒和适宜硒地区农村老年人指甲硒水平随访观察  

Longitudinal observation of nail selenium level of rural elderly population in environmental low selenium and optimal selenium areas

作　　者：苏丽琴[1] 梁超轲[1] 程义斌[1] 马凤[1] 陈晨[1] 刘静怡[1] 李平[2] 边建朝[3] 金银龙[1] 

机构地区：[1]中国疾病预防控制中心环境与健康相关产品安全所,北京100050 [2]四川省疾病预防控制中心 [3]山东省地方病防治研究所

出　　处：《中华地方病学杂志》2015年第6期397-400,共4页Chinese Journal of Endemiology

基　　金：美国国立卫生研究院研究项目（R01AG019181）

摘　　要：目的 了解环境低硒地区和适宜硒地区农村老年人指甲硒水平,分析指甲硒水平的影响因素.方法 从山东和四川两省分别选择环境适宜硒地区和环境低硒地区的2 000名农村老年人作为研究对象,于2003-2005年开展基线人群调查,2010-2012年开展随访调查,采集手指指甲样品,分别采用2,3-二氨基萘荧光法和原子荧光法检测硒含量.结果 基线调查总人群（n=2 000）指甲硒含量均值为（0.414±0.183）mg/kg,随访人群（n=1 209）的基线调查时指甲硒含量均值为（0.413±0.181）mg/kg,随访调查时指甲硒含量均值为（0.463±0.183）mg/kg,随访人群指甲硒水平分别高于基线调查总人群和基线调查时的自身水平（P均＜0.05）.基线调查显示,女性指甲硒含量[（0.432±0.186）mg/kg]高于男性指甲硒含量[（0.392±0.176）mg/kg,P＜0.05];非吸烟者指甲硒含量[（0.423±0.187）mg/kg]高于吸烟者指甲硒含量[（0.403±0.177） mg/kg,P＜0.05];非饮酒者指甲硒含量[（0.442±0.176）mg/kg]高于饮酒者指甲硒含量[（0.376±0.185） mg/kg,P＜0.05];指甲硒含量与体质指数呈正相关（r=0.230,P＜ 0.05）,年龄与指甲硒含量的相关性无统计学意义（r=-0.037,P＞0.05）.结论 2010-2012年随访的老人指甲硒水平较2003-2005年略有升高,指甲硒水平可受到性别、吸烟、饮酒、体质指数等多种因素的影响.Objective To observe the nail selenium level of rural elderly population in environmental low selenium and optimal selenium areas,and explore main factors associated with nail selenium level.Methods Two thousand subjects aged 65 or older were recruited from environmental low and optimal selenium rural areas in Sichuan and Shandong provinces.Two surveys were carried out respectively from 2003 to 2005 and from 2010 to 2012.Finger nail samples were collected and the trace amount of selenium was detected with 2,3-diaminonaphthalene fluorometric determination method and atomic fluorescence spectrophotometric method,respectively.Results The average nail selenium level was （0.414 ± 0.183）μg/g for the total population （n =2 000） at baseline,（0.413 ± 0.181）mg/kg for the follow-up population （n =1 209） at baseline and （0.463 ± 0.183）mg/kg at the follow-up.The selenium level of the follow-up population was slightly higher than that of the total population and that of itself at baseline （all P 〈 0.05）.For the total population at baseline,the average nail selenium level was （0.392 ± 0.176）mg/kg for the male and （0.432 ± 0.186）mg/kg for the female,（0.403 ± 0.177）mg/kg for the smoker and （0.423 ± 0.187）mg/kg for the non-smoker,0.376 ± 0.185）mg/kg for alcohol consumer and （0.442 ± 0.176）mg/kg for the non-alcohol consumer,a positive correlation between body mass index and nail selenium level was observed （r =0.230,P 〈 0.05）,while no significant correlation between age and nail selenium level was observed （r =-0.037,P 〉 0.05）.Conclusion The nail selenium levels of the follow-up population has grown slightly higher in 7 years,nail selenium level could be affected by several factom including gender,smoking,drinking and body mass index.

关 键 词：硒 环境暴露 指(趾)甲 老年人 

分 类 号：R151[医药卫生—营养与食品卫生学]