冻结步态的帕金森病患者多巴胺转运体正电子发射断层显像研究  

Dopamine Transporter PET Imaging in Patients with Freezing of Gait of Parkinson's Disease

作　　者：林伟[1] 邬剑军[1] 郭思思[1] 唐一麟[1] 关荣源 吴平 左传涛 丁正同[1] 王坚[1] 

机构地区：[1]复旦大学附属华山医院神经科,200040 [2]复旦大学附属华山医院PET中心,200235

出　　处：《中国临床神经科学》2015年第3期268-273,共6页Chinese Journal of Clinical Neurosciences

摘　　要：目的探讨帕金森病(PD)冻结步态的临床及多巴胺转运体显像特征。方法选取复旦大学附属华山医院PD数据库中的30例原发性PD患者,分为冻结步态(FOG+)组(11例)和无冻结步态(FOG--)组(19例)。分别对两组患者进行11C-CFT-DAT显像和临床运动评分,对11C-CFT-DAT显像结果与临床运动评分进行相关性分析。结果 FOG+组尾状核的纹状体不对称指数(SAI)显著增高(P=0.004);UPDRS运动评分与重侧(受累严重肢体对侧)尾状核与前壳核比值呈正相关(P=0.034);NFOGQ评分与重侧尾状核SAI呈负相关(P=0.020);冻结步态与尾状核SAI呈显著负相关(P=0.028)。结论双侧尾状核不对称性损害是导致PD患者冻结步态的重要原因,冻结步态可能是皮质-纹状体-脑干-躯体通路中不对称性损害的结果。AimTo investigate the characteristics in the Parkinson’s disease （PD） patients with freezing of gait （FOG） by clinical rating and11C-CFT-DAT imaging.MethodsClinical characteristics and11C-CFT uptake were compared between FOG＋ and FOG, and their correlation were evaluated.Results Striatal asymmetry index （SAI） of11C-CFT uptake was statistically in creased in caudate nucleus when compared with the FOG subjects. On the other hand, SAI in caudate was negatively correlated with scores of NFOGQ and posture.ConclusionAsymmetric disruption in caudate nuleus, a key component of cortical-striatum-pons-body system, may play an essential role in the mechanism of freezing of gait.

关 键 词：帕金森病 冻结步态 多巴胺转运体 正电子发射断层显像 

分 类 号：R742.5[医药卫生—神经病学与精神病学]