口蹄疫病毒入侵宿主细胞研究进展  

The Research Progress About Invasion of Foot and Mouth Virus to Cells

作　　者：朱志坚[1,2] 连凯琪[2] 郑海学[2] 杨孝朴[1] 

机构地区：[1]甘肃农业大学动物医学院,兰州730070 [2]中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室,兰州730046

出　　处：《中国生物工程杂志》2015年第5期103-108,共6页China Biotechnology

基　　金：省农牧厅生物技术专项(GNSW-2014-8);国家自然基金(31302118)资助项目

摘　　要：口蹄疫病毒(FMDV)是小RNA病毒科,口蹄疫病毒属的典型成员,是一种基因组大约含有8 400个核苷酸的无囊膜单股正链RNA病毒。大量研究发现识别细胞表面受体并侵入细胞是FMDV感染宿主细胞非常重要的环节;对FMDV而言,利用哪种受体就决定了利用哪种內吞路径。近年来在口蹄疫病毒入侵宿主细胞方面进行了大量研究,在一定程度上解释了口蹄疫病毒感染机制方面的问题,为解决实际生产问题提供了重要依据。对前期工作进行阶段性总结,为后期深入研究口蹄疫病毒致病机制和探索更有效的防治措施提供参考。FMDV is a small, nonenveloped, positive-strand RNA virus belonging to the genus Aphthovirus within the family Picornaviridae. It contains about 8 400 nucleotides. Many studies have found that it is very important for infection that FMDV recognizes its receptor on cellular surface and enters host cell. Endocytic pathways of which FMDV enters host cell by depend on receptors of which FMDV uses to infect host cell. In recent years, there are a lot of work about the invasion of FMDV to host, explaining many problems about infection mechanism of foot and mouth disease, which provides a strong important base for the problem on actual production. The purpose of this paper is to summarized the previous studies, in order to providing reference for further study of pathogenic mechanism about foot-and-mouth disease virus and to exploring more effective prevention and control measures.

关 键 词：口蹄疫病毒 受体 入侵机制 自噬 

分 类 号：Q939[生物学—微生物学]