肠道解痉剂对结肠息肉检出率影响的Meta分析  

Impact of spasmolytic on polyp and adenoma detection during colonoscopy：a meta-analysis

作　　者：许松欣 邓彬[1] 高雪峰[1] 吴大成[1] 丁岩冰[1] 

机构地区：[1]江苏省扬州市第一人民医院消化科,225001

出　　处：《中华胃肠外科杂志》2015年第6期593-596,共4页Chinese Journal of Gastrointestinal Surgery

摘　　要：目的：探讨肠镜检查中肠道解痉剂的使用对结肠息肉检出率的影响。方法检索PubMed、Medline、EBSCO、High Wire Press、OVID、EMBASE、中国知网及万方数据库等有关肠道解痉剂对结肠息肉或腺瘤检出率影响的文献，检索截至2014年7月。采用统一资料提取表，并采用Jadad量表对纳入文献进行质量评价，运用Review manager 5．2软件进行Meta分析。结果共纳入6篇文献，病例总数47509例，其中东莨菪碱组16867例，安慰剂组30642例，Meta分析显示，解痉剂能提高肠镜检查中息肉（OR＝1．24，95％ CI：1．19～1．30）、腺瘤（OR＝1．25，95％ CI：1．19～1．30）及高危腺瘤的检出率（OR＝1．22，95％ CI：1．16～1．29）。结论肠镜检查中使用解痉剂东莨菪碱可以提高结肠息肉及腺瘤的检出率。Objective To investigate the impact of intestinal spasmolytic on colon polyps and adenoma detection rate during colonoscopy. Methods Literatures related to the effect of intestinal spasmolytic on colon polyp or adenoma detection rate were retrieved from PubMed, Medline, EBSCO, High Wire Press, OVID, EMBASE, and the China National Knowledge Articles, etc. published before July 2014. Unified data were extracted by two researchers independently and organized using Jadad scale to evaluate the quality of the enrolled studies through Review manager 5.2 Meta-analysis software. Results Six articles were enrolled with total 47,509 cases, including 16,867 cases in the scopolamine group and 30,642 cases in the placebo group. Meta analysis showed spasmolytic could increase the detective rate of polyps （OR=1.24, 95% CI：1.19-1.30）, adenoma （OR=1.25, 95% CI：1.19-1.30） and high-risk adenoma （OR=1.22, 95% CI：1.16-1.29）. Conclusion Using colonoscopy spasmolytic scopolamine can increase the detection rate of colonic polyp and adenoma.

关 键 词：解痉剂 东莨菪碱 结肠息肉 结肠腺瘤 结肠镜 

分 类 号：R574.62[医药卫生—消化系统] R735.35[医药卫生—内科学]