视网膜脱离手术前后黄斑中心凹厚度与mf-ERG中央反应研究  

The study between central foveal thickness and multifocal electroretinogram in retinal detachment surgery

作　　者：刘刚贾万程陆卫兴周梅娟裴响华 

出　　处：《中国实用眼科杂志》2015年第6期595-597,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的探讨累及黄斑区的孔源性视网膜脱离（RRD）患眼视网膜黄斑中心凹厚度与多焦视网膜电图（mf-ERG）中央反应波的相关洼。方法临床病例系列研究。对2012年3—12月在上海交通大学附属第六人民医院南院眼科累及黄斑区的RRD16例（16只眼）行巩膜外加压术视网膜复位的患者。手术前与手术后1、3、6个月行频域OCT及mf-ERG检测，观察RRD患者手术前后黄斑区结构与视功能的变化，分析黄斑中心凹厚度与中央反应波振幅密度及潜伏期的相关性。结果手术后1、3、6个月RRD患者黄斑中心凹厚度较术前明显降低差异均有统计学意义（t=10．112、18．794、23．234，均P=0．05）；1环N1波和P1波振幅密度较手术前明显提高（t=-27．28、-92．992，-29．794、-94．942，-61．416、-88．672；均P=O．05），潜伏期较手术前缩短（t=32．280、22．262，17．820、23．858，18．947、8．063；均P=0．05），差异均有统计学意义。手术后1、3、6个月患者黄斑中心凹厚度与1环N1波和P1波振幅密度差异有统计学意义（r=-0．534、-0．667，P=0．033、0．005；r=-0．611、-0．679，P=0．012、0．004；-0．500、-0．668，P=0．049、0．005），与潜伏期差异无统计学意义（r=0．255、0．027，P=0．340、0．922；r=0．300、0．058，P=0．258、0．876；r=0．402、0．458，P=0．123、0．074）。结论OCT和mf-ERG联合应用能全面准确地评估视网膜脱离患者黄斑区结构和功能。Objective To explore the correlation between central foveal thickness and central re- action relevance waves with multifocal electroretinogram （mf-ERG） in patients with rhegmatogenous retinal detachment （RRD） involving the macular area. Methods Clinical case series study of 16 pa- tients （16 eyes） with RRD involving the macular area underwent scleral buckling surgery, mf-ERG and OCT examination were performed before and 1, 3, 6 months after surgery. The changes of the structure and visual function in the macular area were observed in RRD patients before and after sur- gery. The correlations between macular foveal thickness and central reaction relevance waves were an- alyzed. Results Compared with before surgery, postoperative 1, 3, 6 months, the foveal retinal thick- ness after surgery decreased significantly, the differences were statistically significant （t =10.112, 18.794, 23.234, all P =0.05）; N1 and P1 wave amplitude density at ring 1 improved （t =-27.28,-92.992,-29.794,-94.942,-61.416,-88.672; all P =0.05）, the incubation period reduced than before surgery （t =32.280, 22.262, 17.820, 23.858, 18.947, 8.063; all P =0.05）, the differences were statistically significant. Postoperative 1, 3, 6 months, N1 and P1 wave amplitude density at ring 1 with central foveal thickness showed negative correlation （r =-0.534, -0.667, P =0.033, 0.005;r =-0.611,-0.679, P =0.012, 0.004; r =-0.500,-0.668, P =0.049, 0.005）, and there was no correla- tion between central foveal thickness and the incubation period （r=0.255, 0.027, P =0.340, 0.922; r =0.300, 0.058, P =0.258, 0.876; r =0.402, 0.458, P =0.123, 0.074）. Conclusions OCT and mfERG binding applications can assess the structure and function in the macular area in patients with retinal detachment comprehensively and accurately.

关 键 词：多焦视网膜电图 视网膜脱离 黄斑 光学相干断层扫描 

分 类 号：R774.12[医药卫生—眼科]