光动力疗法治疗高原地区新生血管性年龄相关性黄斑变性疗效观察  

The research of photodynamic therapy on neovascular age-related macular degeneration in plateau area

作　　者：宋娅琴[1] 李凌[1] 马雪英[1] 关瑞娟[1] 

机构地区：[1]青海省人民医院眼科,西宁市810007

出　　处：《中国实用眼科杂志》2015年第6期643-646,共4页Chinese Journal of Practical Ophthalmology

摘　　要：目的研究光动力疗法（PDT）治疗高原地区新生血管性年龄相关性黄斑变性（AMD）的临床疗效。方法开放性非对照研究。对2010年12月至2013年5月在青海省人民医院采用PDT治疗新生血管性AMD的患者44例47只眼，随访半年的临床疗效。其中，经典为主型（典型CNV≥整个病灶的50％）31只眼（31／47占65．96％），微小经典型（典型CNV〈整个病灶的50％）16只眼（16／47占34．04％）。治疗前视力0．02—0．6，病灶平均最大线性距离（GLD）为950．0～2712．3μm。结果47只眼随访半年，术后视力稳定41只眼（41／47占87．23％），下降6只眼（6／47占12．77％）；术后眼底荧光血管造影（FFA）和吲哚菁绿血管造影（ICGA）渗漏无增加44只眼（44，47占93．62％），渗漏增加3只眼（3／47占6．38％）。治疗后中心视网膜厚度（CRT）明显降低，差异具有统计学意义（t=11．07。P〈0．01）。有2例术后发生腰背部酸痛反应，不良反应发生率为4．26％（2／47）。结论PDT可以有效治疗高原地区新生血管性AMD，减轻新生血管的渗漏，保持AMD患者视力稳定，无明显不良反应发生，治疗安全；但治疗后仍有复发需再次治疗。Objective To study the clinical efficacy about photodynamic therapy （PDT） in the treatment of neovascular age-related macular degeneration （AMD） in the plateau region. Methods The open controlled study. The clinical efficacy about 44 cases AMD of 47 eyes treated with PDT in Qinghai province people＇s hospital from December 2010 to May 2013, followed up for half a year. Among them, typicality mainly CNV were 31 eyes （31/47, 65.96%）, mildly abnormal CNV 16 eyes （16/47, 34.04%）. The former vision was 0.02 to 0.6, lesions average maximum linear distance （GLD） of （950.0-2712.3）p,m. Results Forty-seven eyes were followed up for half a year, visual acu- ity of 41 eyes （41/47, 87.23%） was stable postoperatively, 6 eyes （6/47, 12.77%） felled; no fundus fluorescence angiography （FFA） and indocyanine green angiography （ICGA） leakage increased in 44 eyes that accounted for 93.62% （44/47） postoperatively, while 3 eyes had leakage increased that ac- counted for 6.38% （3/47）. Central retinal thickness （CRT） decreased after treatment significantly, the difference was statistically significant （t =11.07, P 〈0.0l）; 2 cases had postoperative lumbar back pain reaction, and the incidence of adverse reactions was 4.26% （2/47）. Conclusions It is effective by PDT treatment neovascular AMD in plateau area, creduce the leakage of new blood vessels, keep- ing AMD vision in patients with stable, no obvious adverse reaction occurred, is security. However, there is still a relapse after treatment which needs treatment again.

关 键 词：光动力疗法 年龄相关性黄斑变性 高原地区 

分 类 号：R774.5[医药卫生—眼科]