Receptor-mediated increase in rabies virus axonal transport  

作　　者：Shani Gluska Stefan Finke Eran Perlson 

机构地区：[1]Department of Physiology and Pharmacology,Sackler Faculty of Medicine,and the Sagol School of Neuroscience,Tel Aviv University [2]Friedrich-Loeffler-Institut,Federal Research Institute for Animal Health,Institute of Molecular Virology and Cell Biology

出　　处：《Neural Regeneration Research》2015年第6期883-884,共2页中国神经再生研究（英文版）

基　　金：supported by the German Israeli Foundation for Scientific Research and Development(GIF)grant G-1107-73.1/2010 to EP and SF;The European Research Council(ERC)grant 309377 and Israel Science Foundation ISF grant 614/11 to EP

摘　　要：Rabies virus （RABV） of the rhabdoviridae family is a prototype neurotropic virus that causes a fatal disease, and is still a major risk mostly in developing countries. A key step in the RABV infection process is its arrival into the central nervous system （CNS）, for which it uses the cellular transport machinery. Neurons are irregular cells with a specialized anatomy, and often extend lengthy axons that may span over a meter long. In infected organisms, RABV virions enter the neuron periphery at the area of a bite and must overcome great distances in order to reach the peripheral neuron＇s cell body and from there,Rabies virus （RABV） of the rhabdoviridae family is a prototype neurotropic virus that causes a fatal disease, and is still a major risk mostly in developing countries. A key step in the RABV infection process is its arrival into the central nervous system （CNS）, for which it uses the cellular transport machinery. Neurons are irregular cells with a specialized anatomy, and often extend lengthy axons that may span over a meter long. In infected organisms, RABV virions enter the neuron periphery at the area of a bite and must overcome great distances in order to reach the peripheral neuron＇s cell body and from there,

关 键 词：NCAM Receptor-mediated increase in rabies virus axonal transport NGF GDNF 

分 类 号：R373[医药卫生—病原生物学]