This work was supported by the grants from the National Natural Science Foundation of China(Nos.82172828 and 32271338);Science Foundation for Distinguished Young Scholars of Shaanxi Province(No.2021JC-39);the Natural Science Foundation of Shaanxi Province(No.2022JQ-205);Shaanxi Innovation Team Project(No.2023-CX-TD-58);Shaanxi Fundamental Science Research Project for Chemistry&Biology(Nos.22JHQ077 and 23JHQ042).
Neural cell adhesion molecule(NCAM),a common mammalian cell surface glycoprotein,is the major substrate of polysialic acid(polySia).Polysialylated NCAM occurs in many types of cancer,but rarely in normal adult tissues...