同步放化疗与序贯化放疗治疗Ⅲ期不能手术非小细胞肺癌的临床疗效  

Comparison of the Curative Effect of Concurrent Chemoradiotherapy and Sequential Chemoradiotherapy in Non-small Cell Lung Cancer

作　　者：白桦 侯敏全[2] 白晓宁[2] 张三印[3] 

机构地区：[1]陕西省富平县医院呼吸内科,陕西富平711700 [2]西安交通大学第一附属医院呼吸内科,陕西西安710061 [3]成都中医药大学医学科学部,四川成都611137

出　　处：《昆明医科大学学报》2015年第6期42-45,共4页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81001497)

摘　　要：目的分析比较同步放化疗和序贯放化疗对非小细胞肺癌的疗效和毒副反应.方法选取2010年5月到2013年3月湖南省常德市肿瘤医院收治的不能进行手术切除的Ⅲ非小细胞肺癌患者64例,随机分为同步组和序贯组.同步组患者32例,在放疗开始后第1、4、7周给予吉西他滨和顺铂进行化疗;序贯组患者32例,接受化疗3个周期后开始放疗.结果同步组和序贯组有效率分别为68.8%和43.8%,2组比较差异有统计学意义(P<0.05);同步组患者毒副反应的发生率高于序贯组,其中血液毒性反应同步组发生率为100%,序贯组为65.6%,2组之间存在差异有统计学意义(P<0.05),2组患者放射性肺炎和放射性食管炎的发生率差异无统计学意义(P>0.05).结论同步放化疗对非小细胞肺癌的近期疗效与序贯组相比存在明显优势,同步放化疗是一种安全有效的治疗Ⅲ期非小细胞肺癌的方法.Objective To analyze the curative effect and toxicity of concurrent chemoradiotherapy and sequential chemoradiotherapy in non- small cell lung cancer patients. Methods 64 patients with unresectable stageⅢ non- small cell lung cancer in our hospital between May 2010 and Mar 2013 were randomly assigned into concurrent group and sequential group for this test. Concurrent group patients（32 cases） were given Cisplatin and Gemcitabine on the 1, 4, 7 week during radiotherapy. Sequential group patients accepted 3 cycles chemotherapy before radiotherapy. Results The response rate was 68.8% in concurrent group, and 43.8% in sequential group.Difference was significant between the response rates of the two groups（P〈0.05）. There was significant difference in haematological toxicity, which was 100% in concurrent group and 65.6% in sequential group（P〈0.05）. There was no significant difference in rates of radiation pneumonia and radiation esophagitis in the two groups（P〉0.05）.Conclusions Concurrent chemoradiotherapy has better curative effect than sequential chemoradiotherapy.Concurrent chemoradiotherapy is a safe and effective treatment for patients with unresectable stage Ⅲ non- small cell lung cancer.

关 键 词：非小细胞肺癌 同步放化疗 序贯放化疗 

分 类 号：R734.2[医药卫生—肿瘤]