探讨睾丸交界性黏液性肿瘤临床特征  

The Clinicopatho Logic Characteristics of Testicular Borderline Mucinous Tumor

作　　者：沈红[1,2] 程涛 王忠文 王芳[2] 

机构地区：[1]昭通市第一人民医院病理科,云南昭通657000 [2]昆明医科大学基础医学院病理学教研室,云南昆明650500

出　　处：《昆明医科大学学报》2015年第6期66-70,共5页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81260361);云南省应用基础研究基金资助项目(2010CD079)

摘　　要：目的探讨睾丸交界性黏液性肿瘤的临床病理学特征、诊断及预后.方法对1例睾丸交界性黏液性肿瘤组织行En Vision两步法免疫组化染色,并复习相关文献.结果右侧睾丸缓慢生长伴偶有疼痛,组织学上,肿瘤组织边界清楚,包膜完整,呈多囊性,囊壁被覆小肠型上皮,部分为单层柱状,部分呈乳头状增生,伴细胞增生呈复层,上皮细胞轻-中度异型,无实性细胞团及间质浸润,未见病理性核分裂.免疫表型:PCK、CEA、CA19-9(+)、Cg A示腺上皮内散在神经内分泌细胞(+),Actin示腺体周围增生的平滑肌(+),ki-67增殖指数为45%,Vimentin、PSMA、PLAP、AFP、Calretinin、MC、Syn(-).结论睾丸的原发性黏液性肿瘤少见,但就现有的资料看来,睾丸的这类肿瘤的形态学谱系、分类都与对应的卵巢上皮性肿瘤类似,预后也可能与对应的卵巢上皮性肿瘤类似,鉴别诊断还需要紧密联系临床特点及影像学检查.Objective To investigate the clinicopathologic features, diagonsis and prognosis of testicular borderline mucinous tumor. Methods One case of testicular borderline mucinous tumor tissue was prepared for En Vision two- step immunohistochemical staining, and the pertinent literature was reviewed. Results The right testis grew gradually with occasional pain. Histologically,the boundary of the tumor tissues was clear,the capsule was complete,the tumor was consisted of multiple cavities, the cavities were lined by intestinal- type epithelium,some were single- layer columnar epithelium, some were papillary proliferation and pseudostratification with mild- moderate nuclear atypia were present. There was no solid cell nests, stromal invasion or pathologic mitosis.Immunophenotype： PCK, CEA, CA19- 9 were positive in tumor epithelium, the scattered neuroendocrine cells stained with Cg A, Actin was positive in the smooth muscle around the tumor epithelium. Ki- 67 showed 45% of labeled nuclei of tumor cells. VIMENTIN, PSMA, PLAP, AFP, Calretinin, MC, Syn were carried out with negative results.Conclusions The primary testicular mucinous tumor is rare, but as for the existing data, this type of testicular tumor resembles the ovarian counterparts,exhibits the same morphologic spectrum,classification,and the prognosis is probably the same. It is very important for the differential diagnosis to closely link the clinical characteristics and imageological detection.

关 键 词：睾丸肿瘤 交界性黏液性肿瘤 临床病理 鉴别诊断 

分 类 号：R737.21[医药卫生—肿瘤] R365[医药卫生—临床医学]