肥胖和结直肠癌:流行病学证据和病理生理机制  

Obesity and colorectal cancer: epidemiological evidences and pathophysiological mechanisms

作　　者：钱文彪[1] 刘丹[1] 杜雅菊[1] 

机构地区：[1]哈尔滨医科大学附属第二医院消化内科,黑龙江哈尔滨150086

出　　处：《胃肠病学和肝病学杂志》2015年第6期627-630,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：结直肠癌(colorectal cancer,CRC)是世界范围内最常见的恶性肿瘤之一,近几十年来发病率在亚洲国家中明显上升。大量流行病学证据指出西方化的生活方式和由其导致的超重或肥胖与CRC的发生、发展和预后有一定关系。目前,胰岛素抵抗和高胰岛素血症可能起了中心作用,而胰岛素样生长因子(insulin-like growth factor,IGF)、性激素、脂肪组织来源的因子—瘦素和脂联素、炎症因子和核因子-κB(nuclear factor-κB,NF-κB)信号通路也对CRC的发生、发展和预后产生了一定作用。本文就肥胖与CRC关系的流行病学证据及病理生理机制作一概述。Colorectal cancer is one of the most frequent malignancies worldwide, and its incidence is obviously in- creasing in Asian countries in recent decades. Amounts of epidemiological evidences indicate that westernized lifestyle and resulting overweight or obesity are responsible for the development of colorectal cancer and related to poor prognosis. Currently, it seems that insulin resistance and resultant hyperinsulinemia are likely to play central roles, and IGF, sex- steroids, adipocytes-derived factors such as leptin and adiponectin, inflammatory markers and NF-KB pathway also con- tribute to the development and progression of colorectal cancer. Here, the epidemiological evidences and pathophysiolog- ical mechanisms linking between obesity with colorectal cancer were reviewed.

关 键 词：肥胖 结直肠癌 流行病学证据 机制 

分 类 号：R735.3[医药卫生—肿瘤]