促肾上腺激素释放因子信号在肠易激综合征中的作用  

Role of corticotropin-releasing factor signaling in irritable bowel syndrome

作　　者：张琴[1] 贺国斌[1] 

机构地区：[1]川北医学院附属医院消化内科,四川南充637000

出　　处：《胃肠病学和肝病学杂志》2015年第6期641-644,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：肠易激综合征(irritable bowel syndrome,IBS)的主要病理生理学机制为胃肠动力学异常和内脏高敏感性,它的主要症状是长期反复上腹痛和肠道功能失调,且症状在焦虑或紧张状态下易加重或激发。越来越多的临床前和临床研究表明外周和中枢的促肾上腺激素释放因子(corticotropin-releasing factor,CRF)信号通过自主神经系统、肠道神经系统和免疫系统的活动可能促进IBS症状的发生及发展,现就紧张状态下肠道运动功能及内脏敏感性改变与CRF之间的关系作一概述。The major pathophysiology of irritable bowel syndrome （IBS） is abnormal gastrointestinal motility and vis- ceral hypersensitivity, which is characterized by chronic recurrent symptoms of abdominal pain and bowel dysfunction, and often triggered or exacerbated during periods of stress and anxiety. Growing preclinical and clinical reports indicate that central and peripheral corticotropin-releasing factor （CRF） signaling may contribute to the occurence and develpo- ment of IBS through the activity of autonomic neverous symptom, enteric nervous symptom and immune system. The role of CRF in stress-related alterations of gut motor function and visceral sensitivity was reviewed in this paper.

关 键 词：肠易激综合征 促肾上腺激素释放因子信号 CRF受体拮抗剂 

分 类 号：R574[医药卫生—消化系统]