溃疡性结肠炎患者血清PCT、TNF-α水平及临床意义  

Clinical significance of serum PCT,TNF-α levels in the patients with ulcerative colitis

作　　者：周霞[1] 张绍武[1] 李治国[1] 

机构地区：[1]中国医科大学附属第四医院检验科,辽宁沈阳110032

出　　处：《胃肠病学和肝病学杂志》2015年第6期691-693,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的研究溃疡性结肠炎(ulcerative colitis,UC)患者血清中降钙素原(procalcitonin,PCT)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)水平变化,探讨其临床意义。方法对94例UC患者和20名健康体验者(对照组)进行血清PCT、TNF-α的检测。结果 94例UC患者血清TNF-α、PCT水平均有不同程度的升高;UC活动期血清PCT、TNF-α水平明显高于缓解期和对照组,差异有统计学意义(P<0.05);血清PCT、TNF-α水平随活动期病情严重程度的加重而升高;UC缓解期与对照组相比,差异无统计学意义(P>0.05);血清PCT与TNF-α水平呈正相关,且与疾病严重程度有一定的相关性。结论血清TNF-α、PCT的水平变化可以准确地反映UC患者临床严重程度,为UC患者的诊疗、控制病情发展及判断预后提供重要的理论依据。Objective To evaluate the clinical significance of serum PCT, TNF-α levels in patients with ulcerative colitis （UC）. Methods Ninety-four cases of UC patients and 20 cases healthy controls of serum PCT, TNF-α were de- tected. Results Results of UC patients of serum TNF-α, PCT levels were elevated in varying degrees. The levels of PCT and TNF-α in patients with active phase UC were significantly higher than that of patients with catabasis UC and healthy controls （P 〈 0.05 ）. Catabasis UC compared with the control group was no significant difference （P 〉 0.05 ）. There was significant positive correlation between PCT and TNF-α, and with disease severity also had some relevance. Conclusion Serum PCT, TNF-α levels can accurately reflect the clinical severity of UC patients for clinical treatment.

关 键 词：溃疡性结肠炎 降钙素原 肿瘤坏死因子-Α 

分 类 号：R735.5[医药卫生—肿瘤]