自组装肽的止血应用  

Application of Self-assembling Peptides to Hemostasis——Review

作　　者：甘慧[1] 孟志云[1] 吴卓娜[1] 朱晓霞[1] 顾若兰[1] 孙文种[1] 窦桂芳[1] 

机构地区：[1]军事医学科学院野战输血研究所,北京100850

出　　处：《中国实验血液学杂志》2015年第3期903-909,共7页Journal of Experimental Hematology

基　　金：国家自然科学基金(51273213);北京市科委科技新星项目(Z121107002512050);国家科技重大专项"重大新药创制"项目(2013ZX09J13110-08B);军队后勤科研项目(CWS12J112)

摘　　要：分子自组装作为一种普遍存在于生命体系中的现象,已成为化学、生物学、材料学和医学等多学科研究的交汇点。近年来,肽分子自组装技术的快速发展,使其在组织工程、药物缓释、仿生医学、美容领域、光学和电子产品开发等方面均显示出巨大的应用潜力,尤其自组装肽在脏器、神经与脑部出血创伤救治上的显著疗效,极大地推进行了其在材料科学和临床医学领域的应用。本文将对自组装肽在不同出血创伤模型中的止血效果与性能特点、作用机制、优缺点及其发展趋势做一综述。As a widespread phenomenon in living system, molecular self-assembly has become the meeting point of multidisciplinary research including chemistry, biology, materials science and medicine. In recent years, the rapid development in molecular self-assembly of peptide technology is showing a great potential in the application of tissue engineering, drug delivery, bionic medicine, cosmetology field, optical and electronic product development, etc. Especially, the remarkable hemostatic effect of self-assembling peptides （SAP） on organs, nerves and brain wounds successfully promoted its application to the material science and clinical medicine. This review focuses on the hemostatic effects and characteristics of SAP on different bleeding wound models, action mechanism, its benefits and limitations as well as its adrancing trends.

关 键 词：自组装 多肽 止血 纳米止血剂 

分 类 号：R973.1[医药卫生—药品]