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机构地区:[1]新疆维吾尔自治区人民医院临床检验中心,新疆乌鲁木齐830001 [2]乌鲁木齐市友谊医院心内三科,新疆乌鲁木齐830001
出 处:《中国热带医学》2015年第6期728-729,745,共3页China Tropical Medicine
基 金:新疆维吾尔自治区人民医院科研项目(No.20130116)
摘 要:目的探讨分析前列腺癌患者淋巴细胞亚群的变化与意义。方法对157例前列腺癌患者进行全身核素骨显像,前列腺癌患者和50例健康对照者采用流式细胞术检测外周血淋巴细胞亚群,采用电化学发光免疫分析法测血清总前列腺特异抗原(T-PSA)和游离前列腺特异抗原(F-PSA)的水平。结果前列腺癌骨转移III、IV级患者与I、II级患者、对照组相比,CD3+T淋巴细胞数降低,T-PSA、F-PSA水平升高,而CD4/CD8比值和F-PSA/TPSA水平逐级降低,差异均有统计学意义(P<0.05)。结论前列腺癌骨转移严重患者机体细胞免疫功能明显降低,监测细胞免疫功能,尤其是CD4/CD8比值对前列腺癌患者的治疗和预后有重要临床价值。Objective To explore the changes and significance of lymphocyte subsets in prostate cancer patients. Methods Bone scanning was performed in 157 prostate cancer patients and the lymphocyte subsets in prostate cancer patients and 50 cases of healthy controls were detected by flow cytometry (FCM), serum total prostate-specific antigen (T- PSA) and free prostate specific antigen (F-PSA) were detected by electrochemilumineseence immunoassay. Results The number of CD3+T lymphocyte was less and the level of T-PSA and F-PSA were significantly higher in prostate cancer patients with grade III and IV bone metastases than that with grade I and grade II and healthy control, while the ratio of CD4/CD8 and F-PSAfr-PSA level were significantly reduced (P〈0.05). Conclusions The immune function of prostate cancer patients would be significantly reduced with the progress of bone metastasis, and monitoring cellular immune function, especially change of the CD4 / CD8 ratio possesses essential clinical value in treatment and prognosis of the disease.
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